Elevated Levels of Alpha Cells Emanating from the Pancreatic Ducts of a Patient with a Low BMI and Chronic Pancreatitis

Cell Transplantation
M'Balu A WebbAshley R Dennison

Abstract

Chronic pancreatitis (CP) is an inflammatory disease that causes progressive damage to the pancreatic parenchyma with irreversible morphological changes and fibrotic replacement of the gland. The risk factors associated with developing CP have been described as toxic (e.g., alcohol and tobacco); idiopathic (e.g., unknown); genetic, autoimmune, recurrent acute pancreatitis, and obstructive (the TIGAR-O system). Upon histological screening of the pancreata from a cohort of CP patients who had undergone pancreatectomy for the treatment of intractable pain in Leicester, UK, one sample showed a striking change in the morphological balance toward an endocrine phenotype, most notably there was evidence of substantial α cell genesis enveloping entire cross sections of ductal epithelium and the presence of α cells within the ductal lumens. This patient had previously undergone a partial pancreatectomy, had severe sclerosing CP, an exceptionally low body mass index (15.2), and diabetes at the time the pancreas was removed, and although these factors have been shown to induce tissue remodeling, such high levels of α cells was an unusual finding within our series of patients. Due to the fact that α cells have been shown to be the first end...Continue Reading

References

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Dec 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Akari InadaSusan Bonner-Weir
Sep 26, 2012·Cell Transplantation·M A WebbA R Dennison

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Citations

Aug 28, 2020·World Journal of Diabetes·Ayan RoyBiju Pottakkat

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Methods Mentioned

BETA
pancreatectomy
amputation
biopsy

Software Mentioned

[UNK]
Axiovision

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