Elevated levels of alpha-defensins in plasma and BAL fluid of patients with active pulmonary tuberculosis

Chest
J AshitaniShigeru Matsukura

Abstract

To investigate the role of neutrophil peptides named alpha-defensins in patients with pulmonary tuberculosis (TB). Thirty-seven patients with TB and 25 healthy subjects. Concentrations of alpha-defensins (human neutrophil peptide [HNP]-1, HNP-2, and HNP-3) were measured by radioimmunoassay in plasma and BAL fluid (BALF). Concentrations of alpha-defensins were significantly higher in plasma and BALF of patients with TB than in healthy subjects. In BALF of patients with TB, the concentration of alpha-defensins correlated positively with the levels of interleukin 8, and higher concentrations of alpha-defensins in BALF were also detected in patients with cavitary lesions. There was an inverse relationship between plasma alpha-defensins and FEV(1)/FVC ratio before treatment, and between plasma concentrations of alpha-defensins before treatment and the improvement in percentage of vital capacity after treatment. Plasma alpha-defensin concentrations returned to the normal range after treatment. Our data suggest that alpha-defensins released from neutrophils may play an important role in the pathogenesis of TB, and that plasma alpha-defensin concentration may be a useful marker of disease severity and deterioration of pulmonary function.

References

Sep 1, 1990·The Journal of Infectious Diseases·G S JonesB R Andersen
May 1, 1989·Respiratory Medicine·P A Willcox, A D Ferguson
Aug 1, 1988·The Journal of Infectious Diseases·P F BarnesR L Modlin
Aug 1, 1995·American Journal of Respiratory and Critical Care Medicine·H MukaeK Hara
Aug 1, 1994·Current Opinion in Immunology·T Ganz, R I Lehrer
Sep 30, 1993·Biochemical and Biophysical Research Communications·K ShiomiS Matsukura
Mar 1, 1997·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·L B SoongG H Caughey
Apr 1, 1997·American Journal of Respiratory and Critical Care Medicine·K KurashimaK Matsushima
Dec 24, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T IhiS Matsukura
Mar 28, 1998·American Journal of Respiratory and Critical Care Medicine·R CondosN W Schluger
Dec 10, 1999·The Journal of Allergy and Clinical Immunology·S van WeteringP S Hiemstra

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Citations

Sep 20, 2011·Inflammatory Bowel Diseases·Shinichi HashimotoHirohito Tsubouchi
Aug 24, 2010·Cell and Tissue Research·Linda Hazlett, Minhao Wu
Nov 19, 2013·DNA and Cell Biology·Christelle GabrielLisa F P Ng
May 2, 2009·American Journal of Respiratory and Critical Care Medicine·Stefanos VoglisHaibo Zhang
Mar 1, 2012·Journal of Leukocyte Biology·Christine M Oshansky, Paul G Thomas
Aug 31, 2007·Expert Opinion on Biological Therapy·Christian HerrRobert Bals
Nov 19, 2011·Trends in Immunology·David M LoweAdrian R Martineau
Apr 2, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Irene van den BroekJos H Beijnen
Sep 22, 2007·Biotechnology Journal·Chandra VermaRoger W Beuerman
Dec 18, 2013·Hemodialysis International·Clemens GruppGerhard A Mueller
Feb 24, 2015·Immunological Reviews·JoAnne L FlynnPhilana Ling Lin
Dec 20, 2005·Tuberculosis·Kris L HelkeYukari C Manabe
Oct 13, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Cavan ReillyChris H Wendt
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Christiane I-U ChenRobert Bals
Jul 15, 2016·Journal of Immunology Research·Ehab H MattarElrashdy M Redwan
Aug 5, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tânia Silva, Maria Salomé Gomes
Nov 5, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·L Terry SpencerMark L Brantly
Oct 8, 2009·Journal of Leukocyte Biology·Mona DossKevan L Hartshorn
Sep 28, 2004·The American Journal of Gastroenterology·Hajime IsomotoShigeru Kohno
Nov 24, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Noriho SakamotoShigeru Kohno
Jan 24, 2008·The Journal of Clinical Endocrinology and Metabolism·Gowsini JosephJan Frystyk
Sep 23, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Kieran QuinnHaibo Zhang
Apr 19, 2013·American Journal of Clinical Pathology·Andrew A Renshaw, Edwin W Gould
Sep 23, 2014·BMJ Case Reports·Sarthak DasSubramanian Mahadevan
Jan 8, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Yu-Ting HuJi-Cheng Li
Jun 27, 2008·Clinical and Vaccine Immunology : CVI·Patricia Méndez-SamperioArtemisa Trejo
Nov 28, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Charlotte DentanJean-Luc Bosson
May 27, 2014·BMJ Case Reports·Ines KechaouNarjess Khalfallah
Nov 15, 2016·International Journal of Molecular Medicine·Takuro MaedaAkio Ido

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