Elevated levels of anti-carbamylated protein antibody in patients with rheumatoid arthritis: association with disease activity and bone destruction.

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
Bei ZhangHui Shen

Abstract

To measure the serum levels of anticarbamylated protein (CarP) antibodies in patients with rheumatoid arthritis (RA) in China and to evaluate the association of anti-CarP antibodies with clinical parameters and disease activity. 260 Chinese patients with RA, 40 patients with osteoarthritis (OA), 88 patients with spondyloarthritis (SpA) and 77 healthy controls were included. The serum levels of anti-CarP antibodies were detected by ELISA. Blood tests to detect the anticyclic citrullinated peptide (CCP) antibody level, rheumatoid factor (RF) level, erythrocyte sedimentation rate, C reactive protein level and Disease Activity Score in 28 joints using the erythrocyte sedimentation rate (DAS28-ESR) were performed by standard methods. Bone erosion was assessed by colour Doppler ultrasonography. A total of 18.8% of patients with RA and 9.4% of anti-CCP antibody and RF-double-negative patients were positive for anti-CarP antibody. The anti-CarP antibody level was significantly higher in patients with RA than in patients with OA or SpA and in healthy controls. Univariate and multivariate analyses showed that the level of anti-CarP antibody was positively correlated with DAS28-ESR; the higher a level of serum anti-CarP antibody, the high...Continue Reading

References

Apr 11, 2003·Arthritis and Rheumatism·Marcin SzkudlarekMikkel Østergaard
Oct 15, 2003·Arthritis and Rheumatism·Solbritt Rantapää-DahlqvistWalther J van Venrooij
Sep 11, 2007·Nature Medicine·Zeneng WangStanley L Hazen
May 22, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Piotr MydelMaria Bokarewa
Jul 10, 2010·Arthritis and Rheumatism·Sanna TurunenJuha Risteli
Oct 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jing ShiLeendert A Trouw
Jul 17, 2015·Rheumatology·Marije K VerheulShunichi Shiozawa
Aug 31, 2017·Arthritis & Rheumatology·Marie-Elise TruchetetUNKNOWN Fédération Hospitalo-Universitaire ACRONIM

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