PMID: 9163611May 1, 1997Paper

Elevated levels of basic fibroblast growth factor in megakaryocytes and platelets from patients with idiopathic myelofibrosis

British Journal of Haematology
M C MartyréB Dupriez

Abstract

Idiopathic myelofibrosis, or agnogenic myeloid metaplasia, is a chronic myeloproliferative disorder characterized by clonal expansion and marrow fibrosis. Although marrow fibrosis appears to be a reactive process, it substantially contributes to impaired haemopoiesis. During the last few years the implication of megakaryocyte-derived growth factors in its pathogenesis has been documented. We previously reported increased expression of TGF-beta in patients with idiopathic myelofibrosis. In the present study we show that circulating megakaryocytic cells from such patients expressed high levels of basic fibroblast growth factor (bFGF). An increased expression of bFGF was also detected in patients' platelets. Under culture conditions, bFGF present in megakaryocytic cells was not exported into the medium. consistent with the fact that bFGF is devoid of a secretion peptide signal. Interestingly, this lack of bFGF secretion was observed in all patients but one, who was in an accelerated phase of the disease and presented an important percentage of circulating megakaryoblasts.

Citations

May 25, 2001·International Journal of Hematology·A Tefferi
Jan 5, 2006·Annals of Hematology·Michael A Morgan, Christoph W M Reuter
Sep 5, 2001·Leukemia Research·D P SteensmaA Tefferi
Apr 25, 2001·Pathologie-biologie·M C Le Bousse-KerdilèsUNKNOWN French INSERM research network on Idiopathic Myelofibrosis
Jan 20, 2000·Baillière's Clinical Haematology·J T Reilly
Apr 26, 2002·British Journal of Haematology·Michelle A ElliottAyalew Tefferi
Apr 27, 2000·The New England Journal of Medicine·A Tefferi
Jan 13, 2000·The American Journal of Surgical Pathology·E D RemsteinA G Nascimento
Aug 5, 2000·Current Opinion in Nephrology and Hypertension·R Kalluri, V P Sukhatme
Feb 7, 2013·Current Opinion in Hematology·Fabio P S Santos, Srdan Verstovsek
Dec 23, 2004·European Journal of Haematology·Ching-Liang HoAyalew Tefferi
Oct 2, 2012·The Journal of Clinical Investigation·Xiaoli WangRonald Hoffman
Aug 2, 2008·Blood·Jean-Jacques LatailladeUNKNOWN French INSERM and the European EUMNET Networks on Myelofibrosis
Feb 5, 2005·Cell Communication and Signaling : CCS·Kirugaval C HemavathyJen C Wang
Aug 8, 2006·American Journal of Clinical Pathology·Hongyu NiRonald Hoffman
Sep 1, 2004·Internal Medicine·David DingliAyalew Tefferi
May 29, 2003·Leukemia & Lymphoma·Sujatha A RaoAlbert S Braverman
Dec 29, 2004·Leukemia & Lymphoma·Brijesh AroraAyalew Tefferi
Nov 25, 2003·American Journal of Hematology·Hans Carl HasselbalchElisabeth Ralfkiaer
Apr 30, 1999·Pathology, Research and Practice·K OhshimaM Kikuchi
Mar 31, 2009·Journal of Molecular and Cellular Cardiology·Harald F LangerMeinrad Gawaz
Mar 24, 2009·Annals of Diagnostic Pathology·William R SukovMatthew Lewin
Sep 25, 2007·Cancer Genetics and Cytogenetics·Joris AndrieuxPeter Vandenberghe
May 15, 2007·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·F CognasseO Garraud
Jul 29, 2004·Clinical and Laboratory Haematology·N SayinalpS V Dündar
May 7, 2004·European Journal of Haematology·K PanteliK Bourantas
Apr 11, 2007·European Journal of Haematology·Aline SchmidtDaniel Chappard
Jun 25, 2010·American Journal of Hematology·Jon E PetersonJudah Folkman
Nov 7, 2015·Mediators of Inflammation·Gregor HoermannPeter Valent
Feb 16, 2005·La Revue de médecine interne·X LeleuT Facon
Feb 24, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Bart L ScottH Joachim Deeg
Jun 20, 2006·Best Practice & Research. Clinical Haematology·Hedia ChagraouiWilliam Vainchenker
Jun 20, 2006·Best Practice & Research. Clinical Haematology·Ruben A MesaAyalew Tefferi
Oct 8, 2005·Seminars in Hematology·Giovanni Barosi, Ronald Hoffman
Dec 8, 2015·Mediators of Inflammation·Christophe DesterkeMarie-Caroline Le Bousse-Kerdilès

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