Elevated levels of C-reactive protein and IL-6 among the antipsychotic medicating schizophrenia patients of Siliguri, West Bengal, India

Nordic Journal of Psychiatry
Jiwan GurungBisu Singh

Abstract

Chronic, low-grade inflammation is a proposed etiological factor associated with schizophrenia. Thus, various studies have been conducted to understand the role of inflammatory process in schizophrenia by using inflammatory maker C-reactive protein (CRP) with conflicting findings. Inadvertently, studies of CRP among the Indian schizophrenia patients are very few. Therefore, the present study was undertaken to investigate the role of inflammatory process among Indian Bengalee schizophrenia patients of Siliguri, using the marker CRP and its stimulating cytokine interleukin-6 (IL-6). In addition, the study also intended to investigate the immunomodulatory effect of antipsychotic medication on serum levels of CRP and IL-6. The serum levels of CRP and IL-6 were measured by Enzyme-Linked Immunosorbent Assay (ELISA) among 67 antipsychotic medicating, 28 psychotropic medication-free schizophrenia patients, and it was compared with 72 age, sex and ethnicity-matched controls. A significantly higher level of CRP and IL-6 were recorded among the antipsychotic medicating patients. Although CRP was found to be higher among the psychotropic medication-free patients than the controls, it was not found to be significant. However, a significantl...Continue Reading

References

Feb 1, 1967·Archives of General Psychiatry·J E OverallP Pichot
Jan 1, 1995·Clinical Microbiology Reviews·R H Yolken, E F Torrey
Jun 14, 2000·Annals of Medicine·T W Du Clos
Jun 12, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David L GarverJennifer A Holcomb
Nov 18, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Cornelis Kluft, Moniek P M de Maat
Feb 9, 2005·Molecular Psychiatry·J L RapoportM R C Psych
May 30, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Qingwei WangQing Song
Dec 14, 2006·JAMA : the Journal of the American Medical Association·Leslie A LangeAlexander P Reiner
Mar 31, 2009·Schizophrenia Research·Rajiv TandonMatcheri S Keshavan
May 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Emilio Fernandez-EgeaBrian Kirkpatrick
Jun 11, 2009·Journal of Clinical Psychopharmacology·David C HendersonDonald C Goff
Jan 27, 2010·International Clinical Psychopharmacology·Stefan LöfflerAnsgar Klimke
May 26, 2010·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Maria Carolina Hardoy, Mauro Giovanni Carta
Jun 29, 2010·Schizophrenia Research·Francisco J DiazBenedicto Crespo-Facorro
May 31, 2011·Psychiatry Research·Mounir H FawziNagwa S Said
Jul 30, 2011·Psychiatry Research·Jaana SuvisaariAntti Jula
Feb 23, 2013·Clinical Schizophrenia & Related Psychoses·Brian J MillerMark H Rapaport
Jul 17, 2013·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Chin-Chuen LinTiao-Lai Huang
Sep 3, 2013·Schizophrenia Bulletin·Marie Kim Wium-AndersenBørge Grønne Nordestgaard
Nov 20, 2013·Neuroscience and Biobehavioral Reviews·Keith A FeigensonSteven M Silverstein
Feb 26, 2014·Psychiatry Research·Bisu Singh, Tapas Kumar Chaudhuri
Dec 17, 2014·Nordic Journal of Psychiatry·Adam WysokińskiIwona Kłoszewska
May 20, 2016·Scientific Reports·Masatoshi InoshitaTetsuro Ohmori
Sep 14, 2016·Brain, Behavior, and Immunity·Stephen A MetcalfGolam M Khandaker
Oct 18, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Tarek K RajjiAriel Graff-Guerrero

❮ Previous
Next ❯

Citations

Nov 19, 2019·Nordic Journal of Psychiatry·Rafael Ribeiro-SantosJoão Vinícius Salgado
Mar 18, 2020·Acta Neuropsychiatrica·Mario Gennaro MazzaMassimo Clerici

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here