Elevated levels of circulating cell adhesion molecules in uncomplicated essential hypertension

American Journal of Hypertension
C A DeSouzaD R Seals

Abstract

Elevated levels of circulating soluble cell adhesion molecules are associated with the development of cardiovascular disease. We tested the hypothesis that circulating levels of soluble cell adhesion molecules are elevated in older men with uncomplicated essential hypertension, which may contribute to the increased risk of atherosclerosis in this population. Circulating levels of soluble intercellular adhesion molecule-1, vascular adhesion molecule-1, and E-selectin were measured in 11 hypertensive (69+/-1 years) and ten normotensive (65+/-1 years) older men who were free of overt atherosclerotic disease, diabetes, and dyslipidemia. The hypertensive subjects had higher (P < .05) circulating levels of soluble intercellular adhesion molecule-1 (232.4+/-16.5 v 189.8+/-11.1 ng/mL) and vascular adhesion molecule-1 (737.3+/-65.6 v 565.7+/-46.8 ng/mL) compared with their normotensive peers. However, there was no difference in the levels of soluble E-selectin between the hypertensive (51.1+/-3.9 ng/ mL) and normotensive (48.8+/-6.6 ng/mL) subjects. Univariate analysis revealed a positive correlation between soluble intercellular adhesion molecule-1 and both systolic (r = 0.50, P = .02) and diastolic (r = 0.49, P = .03) blood pressure. ...Continue Reading

Citations

Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·N G ChenG M Reaven
Sep 22, 2001·Hypertension·C U ChaeP M Ridker
Mar 25, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hironobu SanadaTsuyoshi Watanabe
Mar 7, 2007·Clinical Rheumatology·Alaa SabrySherief Refat Elbasyouni
Jul 11, 2007·Journal of Hypertension·Kate M EdwardsPaul J Mills
Nov 17, 2009·Journal of Applied Physiology·Fabien SauvetMounir Chennaoui
Jul 9, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·L E RohdeP M Ridker
Oct 29, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·P ClausenB Feldt-Rasmussen
Nov 7, 2001·Coronary Artery Disease·H M Farouque, I T Meredith
Aug 24, 2002·Coronary Artery Disease·Sarah A HopeNicholas D Balazs
Sep 25, 2003·Journal of Cardiovascular Pharmacology and Therapeutics·Gordon E PateJ Brendan Foley
May 6, 2004·Journal of Hypertension·Michelle A MillerFrancesco P Cappuccio
Dec 3, 2003·Clinical and Experimental Hypertension : CHE·Iván PalomoGloria Icaza
May 24, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hiroki OnoKenji Sunagawa
May 16, 2013·Cell Biochemistry and Biophysics·Magdalena KaczmarskaKvetoslava Burda
May 12, 2012·International Journal of Nephrology·Dinesh SinghSamir El-Dahr
Oct 1, 2009·Indian Journal of Clinical Biochemistry : IJCB·Kavita K ShaliaPriti K Thakur
Apr 24, 2015·Journal of Pediatric Gastroenterology and Nutrition·Mehmet DemircanBulent Mizrak
Oct 17, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·A MazzoneP Zuccaro
Sep 23, 2003·Stroke; a Journal of Cerebral Circulation·Perttu J Lindsberg, Armin J Grau
Feb 26, 2004·Clinical Chemistry·Christoph SchmidMichael Brändle
Aug 27, 2003·The Journal of Clinical Hypertension·Gerald Reaven
Mar 22, 2007·The Journal of Nutrition·Ahmad EsmaillzadehWalter C Willett
Dec 5, 2009·Journal of Human Hypertension·A de la Sierra, M Larrousse
Feb 23, 2013·Mediators of Inflammation·Tsuyoshi Chiba, Keizo Umegaki

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