Elevated levels of collagen cross-link residues in gingival tissues and crevicular fluid of teeth with periodontal disease

European Journal of Oral Sciences
Søren JepsenY Açil

Abstract

Lysylpyridinoline (LP) and hydroxylysylpyridinoline (HP) are collagen cross-link residues. Lysylpyridinoline is present in most tissues, whereas LP is present mainly in mineralized tissue. Both are elevated in tissue with increased collagen resorption. The purpose of this investigation was to assess if the concentrations of LP and HP are elevated in gingiva and gingival crevicular fluid (GCF) of teeth with advanced periodontitis (AP). We investigated human gingival biopsies of healthy teeth (n = 19) and teeth with AP (n = 43) in 49 individuals. Samples of GCF from 54 teeth with AP were collected in seven patients and compared with samples from 11 patients with experimentally induced gingivitis. Levels of LP and HP were measured by HPLC and fluorescence detection. Gingival concentrations of HP but not LP around teeth with advanced periodontitis were significantly elevated compared with teeth with healthy periodontium. While significant amounts of HP and LP were measurable in the GCF of teeth with AP, no HP and LP was identified 3 months following non-surgical periodontal therapy of the teeth or in fluid from teeth subjected to experimentally induced gingivitis. Elevated concentrations of HP and LP in GCF may serve as indicators ...Continue Reading

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Citations

Nov 24, 2004·Calcified Tissue International·Yahya AçilIngo Springer
Mar 11, 2004·Clinical Oral Implants Research·Ingo N G SpringerYahya Açil
Aug 25, 2007·Journal of Clinical Periodontology·Marcela HernándezJorge Gamonal
Feb 26, 2011·Journal of Clinical Periodontology·Nurcan Buduneli, Denis F Kinane
Apr 30, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Nurdan Ozmeric
Apr 10, 2007·International Journal of Oral and Maxillofacial Surgery·I N G SpringerY Acil
Jul 10, 2020·The Journal of Clinical Pediatric Dentistry·Emil KorporowiczSergiusz Jóźwiak
Dec 22, 2009·Journal of Proteome Research·Luan H NgoEric C Reynolds

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