PMID: 8612021Feb 1, 1996Paper

Elevated levels of corticotrophin-releasing factor binding protein in the blood of patients suffering from arthritis and septicaemia and the presence of novel ligands in synovial fluid

British Journal of Rheumatology
R J WoodsP J Lowry

Abstract

In view of the reported inflammatory effects of corticotrophin-releasing factor (CRF) and the associated regulatory elements in the gene of its binding protein (BP), we postulate that both BP as well as novel BP-ligands other than CRF may be involved in inflammatory disease. We have investigated BP in the blood of patients with arthritis and septicaemia and have attempted to identify CRF and other BP-ligands in synovial fluid. The BP was found to be significantly elevated in the blood of patients with rheumatoid arthritis and septicaemia. There was less BP-ligand and CRF in synovial fluid from patients with rheumatoid arthritis that from those with osteo- or psoriatic arthritis. There was at least 10-fold more BP-ligand than CRF in the fluid of all three groups of patients. A small amount of immunoreactive human (h)CRF, eluting in the expected position of CRF-41, was detected after high-pressure liquid chromatography of arthritic synovial fluid; however, the bulk of material with BP-ligand binding activity eluted earlier, suggesting that synovial fluid contained novel peptides that interacted with the BP. These results would suggest that the BP and its ligands could play an endocrine immunomodulatory role in inflammatory disease.

Citations

Apr 9, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Huayuan ZhuShengnan Li
May 1, 1996·Pharmacology, Biochemistry, and Behavior·P J LowryS Baigent
May 5, 2001·Peptides·D S JessopS L Lightman
Apr 25, 2017·Stress : the International Journal on the Biology of Stress·Kyle D KetchesinAudrey F Seasholtz
Apr 15, 2018·European Respiratory Review : an Official Journal of the European Respiratory Society·Maria A KokosiAthol U Wells
May 20, 1998·The Journal of Clinical Endocrinology and Metabolism·P J TrainerA B Grossman
May 1, 1997·The Journal of Clinical Endocrinology and Metabolism·R J WoodsP J Lowry
Apr 28, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sandra Lo ReFrançois Huaux

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