Elevated levels of fibroblast growth factor-2 in serum from women with endometriosis

American Journal of Obstetrics and Gynecology
V BourlevM Olovsson

Abstract

The purpose of this study was to determine whether serum and peritoneal fluid levels of fibroblast growth factor-2 (FGF-2) differ between women with and without endometriosis and to examine the relationship between proliferative activity in the endometriotic lesions and the levels of FGF-2 in serum and peritoneal fluid. Biopsy specimens of peritoneal endometriotic lesions (n = 25) were analyzed immunohistochemically regarding proliferative activity in stroma, glands, and blood vessels. The FGF-2 concentration was measured in peritoneal fluid and serum from 25 women with endometriosis and 14 healthy controls. Patients with endometriosis had higher serum concentrations of FGF-2 during both the proliferative and secretory menstrual phases than healthy women. Peritoneal fluid levels of FGF-2 differed significantly between women with high and low proliferative activity in their endometriotic lesions. Women with endometriosis have a higher serum level of FGF-2 than healthy controls.

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Citations

Jun 28, 2012·Human Reproduction·A VodolazkaiaT M D'Hooghe
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Jan 30, 2018·Human Reproduction Update·Matthias W Laschke, Michael D Menger
May 26, 2021·Obstetrical & Gynecological Survey·Nikolaos ThanatsisApostolos Kaponis

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