Elevated levels of GDF-15 is associated with increased angiotensin II in hypertensive patients with Type 2 diabetes

Personalized Medicine
Ramu AdelaSanjay K Banerjee

Abstract

Circulatory GDF-15, angiotensin II (Ang-II) and GDF-15 mRNA expression levels were examined in three groups, in other words, control (n = 25), Type 2 diabetes (T2DM; n = 25) and Type 2 diabetes with hypertension (T2DM_HTN; n = 36). T2DM and T2DM_HTN subjects had significantly (p < 0.05) higher GDF-15 and Ang-II levels compared with control subjects. Significant positive correlation was found between Ang-II and GDF-15 levels. GDF-15 mRNA expression from blood cells was significantly elevated in T2DM_HTN (p < 0.05) but not in T2DM subjects. GDF-15 mRNA expression was significantly elevated in Ang-II-treated (50 nM) THP-1 (p < 0.001) and H9C2 (p < 0.05) cells but not altered after high glucose treatment. Collectively, our data suggest that higher levels of GDF-15 is associated with increased Ang-II levels in diabetic patients with concurrent hypertension.

References

Dec 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Min YanSanford D Markowitz
Jun 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nicoletta FerrariAdriana Albini
Sep 11, 2007·Journal of the American College of Cardiology·Tibor KempfKai C Wollert
Sep 26, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Rodrigo M LagoRichard W Nesto
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Sep 22, 2010·Aging Cell·Fredrik E WiklundDavid A Brown
Jul 2, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Xinye XuWei Gao
Sep 24, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Samuel N BreitDavid A Brown
Jan 11, 2012·Journal of Neurology·Klaus GröschelRolf Wachter
Aug 15, 2015·Journal of Diabetes Research·Ramu Adela, Sanjay K Banerjee

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Citations

Jul 17, 2020·Frontiers in Cardiovascular Medicine·Shreya SarkarJean-François Légaré

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Methods Mentioned

BETA
ELISA
electrophoresis
PCR

Software Mentioned

SigmaPlot
Step one plus
Graph Pad Prism
primer

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