Elevated Levels of IFN-γ in CSF and Serum of Patients with Amyotrophic Lateral Sclerosis

PloS One
Juan LiuDawei Zang

Abstract

To explore whether the levels of IFN-γ in cerebral spinal fluid (CSF) and serum are elevated in ALS patients and to analyze the correlations between the IFN-γ levels and disease progression. CSF and serum samples were obtained from 52 ALS patients and 31 non-ALS patients. The levels of IFN-γ in CSF and serum were assessed, and disease progression parameters, including the disease interval (months from onset, MFO), the revised ALS Functional Rating Scale (ALSFRS-r) score and the disease progression rate (DPR) were analyzed by registered neurologists. All samples were measured using a commercial enzyme-linked immunosorbent assay. Statistical analyses were performed using Prism software. Compared to the non-ALS patients, the ALS patients displayed significantly increased levels of IFN-γ in both CSF and serum, and these values consistently correlated with disease progression. These results demonstrated that IFN-γ in CSF may serve as a biomarker of ALS differentiation and progression. CSF IFN-γ was a more reliable biomarker of disease diagnosis and progression than serum IFN-γ.

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Citations

Mar 10, 2017·Expert Opinion on Investigational Drugs·Ana MartinezCarmen Gil
Oct 11, 2016·Arthritis Care & Research·Chia-Chun TsengJeng-Hsien Yen
Oct 28, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Piotr LewczukUNKNOWN Members of the WFSBP Task Force Working on this Topic: Peter Riederer, Carla Gallo, Dimitrios Kapogiannis, Andrea Lopez Mato
Jun 2, 2018·Biomolecular Concepts·Gunjan KakBrijendra K Tiwari
Dec 10, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Lucas T Vu, Robert Bowser
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May 30, 2019·Frontiers in Neurology·Udaya Geetha VijayakumarStephanie Marie-Rose Duguez
Mar 16, 2017·Brain and Behavior·Jie GuoDawei Zang
Jan 14, 2021·Scientific Reports·Alexandre BrodovitchAnnie Verschueren
Oct 11, 2017·Journal of the Neurological Sciences·Anuradha TennakoonIan P Johnson
Apr 12, 2019·ACS Sensors·Jennifer MoralesHeather A Clark

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

GraphPad Prism
GraphPad

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