PMID: 9194211Jan 1, 1997Paper

Elevated levels of insulin-like growth factor (IGF) binding protein-3 in rheumatoid arthritis synovial fluid inhibit stimulation by IGF-I of articular chondrocyte proteoglycan synthesis

Rheumatology International
J NeidelJ Föll

Abstract

The objective of this study was to quantify insulin-like growth factor (IGF) binding proteins (IGFBPs) in the synovial fluid (SF) and plasma of patients with rheumatic diseases and to study the role of these proteins in the regulation of cartilage proteoglycan (PG) synthesis. Immunological determination of IGFBP-2, IGFBP-3, IGF-I, IGF-II, interleukin-1 beta (IL-1 beta) and tumour necrosis factor alpha (TNF alpha) was undertaken in the SF and plasma of 115 patients with rheumatoid arthritis (RA; n = 53), osteoarthritis (OA; n = 44) and other rheumatic disorders. We also determined the effects of SF on bovine cartilage PG synthesis in culture. IGFBP-2 and IGFBP-3 were elevated in the plasma (by 38% and 28%, respectively) and SF (by 56% and 59%, respectively) of patients with RA compared to age- and sex-matched OA controls (determined by RIA and confirmed by Western ligand blot). IGF-I and IGF-II did not differ significantly between the two groups. OA SF, and, to a lesser extent, RA SF stimulated cartilage PG synthesis in culture, and more than 60% of this activity was neutralised by a specific monoclonal anti-IGF-I antibody. Human IGFBP-3 dose-dependently inhibited the stimulation of cartilage PG synthesis effected by SF or human...Continue Reading

Citations

Aug 24, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·L A FortierA J Nixon
Apr 7, 2007·Current Opinion in Rheumatology·Gust VerbruggenDirk Elewaut
Mar 15, 2014·Cardiology in the Young·Onur S DeveciDerun T Ertugrul
Jun 9, 2016·Clinical Proteomics·Mitali BhattacharjeeAkhilesh Pandey
Aug 25, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A J NixonH Mohammed

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