PMID: 11411960Jun 20, 2001Paper

Elevated levels of nitrate in rheumatoid arthritis

Rheumatology International
O OnurI Unsal


Nitric oxide (NO) is a free radical that plays important roles in many physiological and pathological processes. Evidence suggests that NO participates in the pathogenesis of inflammatory reactions in many autoimmune and inflammatory diseases such as rheumatoid arthritis (RA). The purpose of this study was to evaluate serum concentrations of NO in patients with RA and to determine whether they correlate with clinical and laboratory parameters of RA disease activity. Twenty-seven RA patients were recruited for the study and compared with 20 healthy subjects. Serum NO concentrations were measured indirectly in terms of nitrate using colorimetric assay. Disease activity was determined by laboratory and clinical findings. Mean serum concentrations of nitrate were significantly higher than those of healthy controls (P < 0.05). Among the disease activity parameters, C-reactive protein, number of swollen and tender joints, Ritchie articular index, and disease activity scores correlated significantly with serum NO levels. Our results suggest that these levels can serve as a reliable parameter of disease activity in patients with RA. Further knowledge about the precise role of NO may lead to better understanding of the pathogenesis of R...Continue Reading


Mar 28, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Howard TrachtmanPravin C Singhal
Feb 2, 2008·Bulletin of Experimental Biology and Medicine·L A BelogolovykhE E Medved'
Apr 9, 2010·International Journal of Rheumatic Diseases·Pallinti VasanthiG Rajasekhar
Aug 16, 2006·Arthritis Research & Therapy·J Brice WeinbergE William St Clair
Jun 15, 2007·Immunology Letters·György NagyAndrew P Cope
Sep 19, 2012·Scandinavian Journal of Rheumatology·M A KhanK Alam
Oct 3, 2012·Osteoarthritis and Cartilage·T P MiskoD Roman
Dec 3, 2014·Revista brasileira de reumatologia·Adel Mahmoud AliRania Hamdy Elkabarity
Oct 15, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gianna FerrettiDavide Neri
Apr 23, 2010·Risk Analysis : an Official Publication of the Society for Risk Analysis·Katsuichiro Goda, Jiandong Ren
Jul 16, 2001·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·P SamoríJ P Rabe
Mar 13, 2014·Molecular and Cellular Biochemistry·Mirjana VeselinovicVladimir Jakovljevic

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.