Elevated Levels of Pentraxin 3 Correlate With Neutrophilia and Coronary Artery Dilation During Acute Kawasaki Disease.

Frontiers in Pediatrics
Lauren L ChingAndras Bratincsak

Abstract

Kawasaki disease (KD) is the leading cause of acquired pediatric heart disease in the developed world as 25-30% of untreated patients and at least 5% of treated patients will develop irreversible coronary artery lesions (CAL). Pentraxin-3 (PTX-3) has been well-studied in inflammatory diseases, particularly in cardiovascular diseases associated with vascular endothelial dysfunction. We hypothesized that PTX-3 plays an important role in the development of KD-associated CAL and investigated the circulating levels of PTX-3 in the serum of KD patients. Children with acute KD were followed from diagnosis through normalization of the clinical parameters of inflammation (convalescent phase). Serum samples were obtained and echocardiograms were conducted at several phases of the illness: acute [prior to intravenous immunoglobulin (IVIG) treatment], sub-acute (5-10 days after IVIG treatment), and convalescent (1-4 months after KD diagnosis). Seventy children were included in the final cohort of the study, of whom 26 (37%) presented with CAL and 18 (26%) developed IVIG resistance. The patients included in this study came from diverse ethnic backgrounds, mostly with mixed ancestry/ ethnicity. Significantly increased PTX-3 levels were obser...Continue Reading

References

Jul 1, 1979·Japanese Circulation Journal·S AmanoY Hamashima
Aug 1, 1979·Japanese Circulation Journal·S AmanoY Hamashima
Dec 1, 1991·Acta Paediatrica Japonica; Overseas Edition·K Harada
Aug 26, 1998·The Journal of Pediatrics·A de ZorziJ W Newburger
Apr 18, 2003·Lancet·Dirk FoellJohannes Roth
Aug 11, 2004·Lancet·Jane C Burns, Mary P Glodé
Sep 18, 2004·The American Journal of Cardiology·Fei YeToshio Miyawaki
Mar 18, 2005·Annual Review of Immunology·Cecilia GarlandaAlberto Mantovani
Apr 6, 2006·Circulation·Ulrich Förstermann, Thomas Münzel
Aug 5, 2006·The Journal of Pediatrics·Kimiyasu EgamiToyojiro Matsuishi
Mar 29, 2007·The Journal of Experimental Medicine·Sébastien JaillonAlberto Mantovani
Jun 20, 2007·Circulation·Brian W McCrindleUNKNOWN Pediatric Heart Network Investigators
Jul 25, 2008·Shock·Tom SprongMarcel van Deuren
Jan 24, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Nancy Swords JennyBruce M Psaty
Nov 17, 2009·Journal of the American College of Cardiology·John B GordonJane C Burns
Jan 19, 2010·Biochemical and Biophysical Research Communications·Elisabetta StrafaceDomenico Del Principe
Jul 27, 2010·Trends in Cardiovascular Medicine·Giuseppe Danilo NorataAlberico Luigi Catapano
Aug 6, 2011·The Pediatric Infectious Disease Journal·Adriana H TremouletJane C Burns
Jan 18, 2012·Pediatrics·Hiromi MutaYosikazu Nakamura
Feb 22, 2012·International Journal of Vascular Medicine·Kenji InoueHiroyuki Daida
Jul 5, 2012·The Pediatric Infectious Disease Journal·Samuel R DominguezMary P Glodé
Nov 17, 2012·Immunity & Ageing : I & a·Annibale Alessandro PucaCarmine Vecchione
Jul 10, 2013·Journal of the American College of Cardiology·Elif Seda Selamet TierneyJane W Newburger
Mar 12, 2016·Stroke; a Journal of Cerebral Circulation·Akihiro ShindoKen Arai
Aug 26, 2016·Immunity & Ageing : I & a·Francesco FornaiCarmine Vecchione
Sep 17, 2016·Journal of the American Heart Association·Kevin G FriedmanJane W Newburger
Oct 4, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martin Prince AlphonseRae S M Yeung
Oct 27, 2016·Immunological Reviews·Kenji DaigoAlberto Mantovani
Jan 8, 2017·Journal of Cellular and Molecular Medicine·Domenico Del PrincipeElisabetta Straface
Mar 31, 2017·Circulation·Brian W McCrindleUNKNOWN American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee of the Council on Cardiovascular Di
Apr 26, 2017·Frontiers in Psychology·Jonathan Z Bakdash, Laura R Marusich
Jun 2, 2017·Journal of the American Heart Association·Mary Beth F SonJane W Newburger

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Citations

May 14, 2021·Clinical & Translational Immunology·Toshiro HaraYasunari Sakai

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Methods Mentioned

BETA
blood collection
Assay
ESR

Software Mentioned

Milliplex Analyst
R
GraphPad
GraphPad Prism

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