Elevated levels of phosphorylated neurofilament heavy subunit in the cerebrospinal fluid of patients with lumbar spinal stenosis: preliminary findings

The Spine Journal : Official Journal of the North American Spine Society
Junichi OhyaToru Ogata

Abstract

The phosphorylated neurofilament heavy subunit (pNfH) is an axon fiber structural protein that is released into the cerebrospinal fluid (CSF) after nerve damage. Although the previous studies have reported elevated CSF levels of pNfH in various neurological diseases, including amyotrophic lateral sclerosis, these levels have not been examined in patients with spinal stenosis. The purpose of this study was to investigate the CSF levels of pNfH in patients with lumbar spinal stenosis (LSS) and to examine the relationship between CSF levels of pNfH and the severity of LSS. This is a prospective observational study. We included consecutive patients with LSS who were undergoing myelography for preoperative evaluation. The CSF samples from patients with idiopathic scoliosis were used as the controls. Physiological measures: CSF levels of pNfH were measured using an enzyme-linked immunosorbent assay. The Zurich Claudication Questionnaire (ZCQ) and the Numerical Rating Scale (NRS) for sciatic pain were used to assess the clinical severity of LSS, and patients were grouped into tertiles according to their symptom severity and pain grading. Axial magnetic resonance imaging was used to evaluate the morphological severity of LSS, and patie...Continue Reading

References

Mar 1, 1987·Journal of Neuroimmunology·M E GoldsteinL A Sternberger
Sep 6, 2003·Journal of Immunological Methods·A PetzoldE J Thompson
May 18, 2005·Journal of the Neurological Sciences·Axel Petzold
Sep 24, 2005·Biochemical and Biophysical Research Communications·Gerry ShawDena R Howland
Mar 3, 2006·The Journal of Bone and Joint Surgery. American Volume·Harry N HerkowitzG Paul Derosa
Jul 18, 2006·Spine·C Martina LohmanKarl-August Lindgren
Feb 3, 2007·The Journal of Bone and Joint Surgery. American Volume·Andrew J HaigVaishali V Phalke
Apr 12, 2007·Spine·Hiroyuki AonoHideki Yoshikawa
Mar 8, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Mustafa SirvanciAzmi Hamzaoglu
Mar 18, 2008·Cellular and Molecular Neurobiology·Yin-Rong YangZhe-Yu Chen
Mar 24, 2010·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Nobuhiro HaraKo Matsudaira

❮ Previous
Next ❯

Citations

Mar 21, 2018·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Hiroshi TakahashiKoichi Nakagawa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Hiroshi TakahashiKoichi Nakagawa
Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
Deise M F MendonçaAna Maria B Martinez
© 2021 Meta ULC. All rights reserved