Elevated levels of serum chemerin in patients with obstructive sleep apnea syndrome

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Xuewei FengJian Kang

Abstract

Chemerin is implicated to be correlated with obesity and inflammation. This study aims to investigate whether serum chemerin is associated with the presence of obstructive sleep apnea syndrome (OSAS). A total of 132 patients with OSAS and 108 healthy subjects were enrolled in this study. Serum chemerin levels were significantly elevated in OSAS patients (120.93 ± 25.84 µg/L vs. 107.51 ± 20.41 µg/L). Multivariable logistic regression analysis revealed that serum chemerin levels were an independent determinant of the presence of OSAS (OR 1.030, 95% CI 1.016-1.045; p < 0.001). Serum chemerin levels in severe OSAS patients were significantly higher compared with those in mild and moderate OSAS patients (p = 0.015 and p = 0.020, respectively). Spearman correlation analysis indicated that serum chemerin levels were correlated with the severity of OSAS (r = 0.210, p = 0.016). Serum chemerin were positively correlated with waist circumference (r = 0.164, p = 0.008), body mass index (r = 0.158, p = 0.014), systolic blood pressure (r = 0.135, p = 0.037), homeostasis model assessment of insulin resistance (r = 0.140, p = 0.031), C-reactive protein (r = 0.202, p = 0.002), and apnea-hypopnea index (r = 0.152, p = 0.022). Elevated serum chem...Continue Reading

References

Apr 1, 1990·Controlled Clinical Trials·W D Dupont, W D Plummer
Jul 1, 1995·The European Respiratory Journal·P C Deegan, W T McNicholas
Dec 21, 2000·JAMA : the Journal of the American Medical Association·P E PeppardJ Skatrud
Jul 23, 2002·Lancet·Atul Malhotra, David P White
Nov 15, 2005·American Journal of Respiratory and Critical Care Medicine·Allan I Pack
Oct 13, 2006·Journal of Endocrinological Investigation·B MasseriniE Orsi
Jul 20, 2007·The Journal of Biological Chemistry·Kerry B GoralskiChristopher J Sinal
Jul 21, 2007·Endocrinology·Kiymet BozaogluDavid Segal
Sep 5, 2007·Biochemical and Biophysical Research Communications·Sang-gun RohShin-ichi Sasaki
Feb 6, 2008·Proceedings of the American Thoracic Society·Naresh M Punjabi
Jun 26, 2008·Respiration; International Review of Thoracic Diseases·Yasushi YamamotoYasuhiro Yamazaki
Feb 17, 2009·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·David StejskalMarek Svestak
May 28, 2009·The Journal of Clinical Endocrinology and Metabolism·Kiymet BozaogluJeremy B M Jowett
Jun 30, 2009·Clinical Endocrinology·Johanna WeigertChrista Buechler
Dec 1, 2009·Oral and Maxillofacial Surgery Clinics of North America·Mansoor Madani, Farideh Madani
Feb 9, 2010·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·C Sunitha, S Aravindkumar
Jun 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tae YamamotoJonas Axelsson
Aug 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rosie Hart, David R Greaves
Dec 15, 2010·Diabetes Research and Clinical Practice·Wenchao Hu, Ping Feng
Mar 29, 2011·Respiratory Physiology & Neurobiology·Brian D KentWalter T McNicholas
Nov 1, 2011·Experimental and Molecular Pathology·Kristina EisingerKlaus W Frommer

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Citations

Dec 12, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J L RourkeC J Sinal
May 29, 2014·The Clinical Respiratory Journal·Banu BoyukVolkan Kucukyalçin
Jan 11, 2014·Scandinavian Journal of Clinical and Laboratory Investigation·Xin Wang, Guo-Hong Xing
Oct 25, 2016·Journal of Molecular and Cellular Cardiology·Michael V G Latronico, Gianluigi Condorelli
Apr 6, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Stephanie W WattsGregory D Fink
Jun 16, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stephanie W WattsGregory D Fink
May 27, 2020·American Journal of Hypertension·David J FerlandStephanie W Watts
Dec 13, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Johann DaxerMirja Quante
Aug 15, 2019·International Journal of Molecular Sciences·Susanne FederChrista Buechler

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