PMID: 8592062Jan 1, 1996Paper

Elevated levels of the endogenous retrovirus ERV3 in human sebaceous glands

The Journal of Investigative Dermatology
Ann-Catrin AnderssonErik Larsson

Abstract

ERV3 (HERV-R) is a complete human endogenous retrovirus located on the long arm of chromosome 7. Long terminal repeat-envelope (env) gene spliced mRNAs of 9 and 3.5 kb are widely expressed in human tissues and cells, but gag-pol mRNAs have not been found. Furthermore, the env gp70 gene contains an open reading frame throughout its length. The highest expression of ERV3 mRNA detected so far is in placenta and the lowest in choriocarcinoma cell lines. We have previously shown that the human monoblastic cell line U-937 and some normal and neoplastic tissues also express high levels of ERV3 env message by Northern blot analysis; however, this method does not distinguish between mRNA expression in different cell types in tissues. In this report, we have studied the ERV3 mRNA expression in specific cell types of human skin by in situ hybridization. We found high levels expression of ERV3 env mRNA in human sebaceous glands in normal skin and dermoid cysts of the ovary. In all glands, the expression is maximal in the periphery of the lobule and ceases towards the center in the region of characteristic holocrine secretion. Since it is known that the regulation of sebaceous glands is primarily via steroid hormones, particularly androgens...Continue Reading

Citations

Jul 29, 1996·International Journal of Cancer. Journal International Du Cancer·E LarssonK Nilsson
Oct 28, 1998·Scandinavian Journal of Immunology·E Larsson, G Andersson
Jul 5, 2005·Journal of Virology·Ann-Catrin AnderssonJonas Blomberg
Oct 3, 2006·International Journal of Cancer. Journal International Du Cancer·Feng Wang-JohanningGary L Johanning
Aug 20, 2009·AIDS Research and Human Retroviruses·Naomi SasakiAkihiro Ishizu
Jan 1, 2006·Expert Review of Clinical Immunology·Antonina Dolei
Jan 31, 2018·Frontiers in Microbiology·Yomara Y Bustamante RiveraMartin S Staege
Sep 25, 1998·Biology of Reproduction·D Taruscio, A Mantovani
Aug 20, 2014·BioMed Research International·Signy BendiksenUgo Moens
Sep 25, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·K KatsumataT Yoshiki

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