Elevated levels of vitamin D and deficiency of mannose binding lectin in dengue hemorrhagic fever.

Virology Journal
K AlagarasuCecilia Dayaraj

Abstract

Altered plasma concentrations of vitamin D and mannose binding lectin (MBL), components of innate immunity, have been shown to be associated with the pathogenesis of viral infections. The objective of the present study was to find out whether plasma concentrations of MBL and vitamin D are different in patients with dengue fever (DF) and dengue hemorrhagic fever (DHF). The plasma concentrations of vitamin D and MBL were assessed in 48 DF cases, 45 DHF cases and 20 apparently healthy controls using ELISA based methods. Vitamin D concentrations were found to be higher among both DF and DHF cases as compared to healthy controls (P < 0.005 and P < 0.001). Vitamin D concentrations were not different between DF and DHF cases. When the dengue cases were classified into primary and secondary infections, secondary DHF cases had significantly higher concentrations of vitamin D as compared to secondary DF cases (P < 0.050). MBL concentrations were not significantly different between healthy controls and dengue cases. MBL concentrations were observed to be lower in DHF cases as compared to DF cases (P < 0.050). Although MBL levels were not different DF and DHF cases based on immune status, the percentage of primary DHF cases (50%) having MB...Continue Reading

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Citations

Feb 6, 2013·Human Immunology·K AlagarasuD Cecilia
Sep 10, 2014·The American Journal of Tropical Medicine and Hygiene·Sundus AhmedSaurabh Mehta
Mar 30, 2018·PLoS Neglected Tropical Diseases·James Weger-LucarelliErik A Karlsson
Aug 15, 2018·The British Journal of Nutrition·Eduardo VillamorOscar F Herrán
Jul 4, 2020·Scientific Reports·Janejira JaratsittisinDuncan R Smith
May 30, 2019·Memórias do Instituto Oswaldo Cruz·Alice Maria de Magalhães OrnelasCynthia Chester Cardoso
May 8, 2020·Tropical Medicine and Infectious Disease·Anita ChakravartiAnzar Ashraf
Dec 2, 2020·The American Journal of Tropical Medicine and Hygiene·Steven D Langerman, Mija Ververs

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Methods Mentioned

BETA
ELISA

Software Mentioned

Graphpad prism
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