Abstract
Familial hypercholesterolemia (FH) is characterized by elevated LDL-cholesterol and increased risk of premature coronary artery disease (CAD). Lipoprotein(a) [Lp(a)] increases CAD in FH, although the independence of this association relative to other CAD risk factors remains unclear. In this study, we examined the association between Lp(a) and other cardiovascular risk factors and prevalent CAD in patients with FH. A cross-sectional study of 390 patients with genetically confirmed FH were studied. Clinical and biochemical parameters of FH patients with and without CAD were compared. FH patients with CAD were older and more often male and had a higher prevalence of hypertension, smoking, diabetes, obesity, reduced eGFR, and elevated plasma Lp(a) and pre-treatment LDL-cholesterol and triglyceride (or low HDL-cholesterol) than FH patients without CAD (P<0.05 for all). In univariate analyses, age, male gender, smoking, hypertension, reduced eGFR, diabetes, obesity, plasma creatinine, Lp(a) and pretreatment LDL-cholesterol, triglycerides and HDL-cholesterol levels were significant predictors of CAD in the FH patients (P<0.05 for all). Elevated LDL-cholesterol, raised Lp(a), hypertension and reduced eGFR remained significant independ...Continue Reading
References
Aug 1, 1995·Circulation·J FerrièresJ Davignon
Jun 1, 1994·The Journal of Clinical Investigation·D J RaderH B Brewer
Jan 1, 1997·Nucleic Acids Research·M VarretC Béroud
Apr 27, 1999·Atherosclerosis·L B Nielsen
Mar 24, 2000·Atherosclerosis·E J SijbrandsA H Smelt
May 2, 2000·Archives of Internal Medicine·C T ValmadridB E Klein
Mar 7, 2001·The American Journal of Cardiology·P N HopkinsS C Hunt
Jan 25, 2003·Journal of Internal Medicine·P R W de Sauvage NoltingJ J P Kastelein
Feb 7, 2003·Journal of the American College of Cardiology·Guruprasad ManjunathMark J Sarnak
Mar 14, 2003·Clinical Biochemistry·Josep M SimóJorge Joven
Jul 16, 2003·The American Journal of Cardiology·Peter H JonesUNKNOWN STELLAR Study Group
Mar 17, 2004·Current Opinion in Lipidology·Marlys L Koschinsky, Santica M Marcovina
Nov 18, 2004·Heart·H A W NeilS E Humphries
Nov 24, 2004·Journal of Internal Medicine·A C M JansenJ J P Kastelein
Sep 17, 2005·Kidney International·Barry M Brenner
Jan 18, 2006·Hypertension·Kambiz Zandi-NejadBarry M Brenner
Feb 15, 2007·Kidney International·M E FrischmannH Dieplinger
Mar 24, 2007·Nature Clinical Practice. Cardiovascular Medicine·Anne K Soutar, Rossi P Naoumova
Feb 5, 2008·Atherosclerosis·R AlonsoUNKNOWN Spanish Familial Hypercholesterolaemia Group
Mar 8, 2008·Annals of Human Genetics·S E A LeighS E Humphries
Nov 6, 2008·Journal of Thrombosis and Haemostasis : JTH·N T FericM L Koschinsky
Apr 13, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Cécilia G MaubaretUNKNOWN HIFMECH consortium, Simon Broome Research Group
Jul 3, 2010·European Heart Journal·Jorie VersmissenEric J G Sijbrands
Oct 23, 2010·European Heart Journal·Børge G NordestgaardUNKNOWN European Atherosclerosis Society Consensus Panel
Mar 8, 2011·Atherosclerosis·Marit S NenseterKjetil Retterstøl
Aug 14, 2012·Atherosclerosis·Amanda J HooperFrank M van Bockxmeer
Aug 21, 2012·The Medical Journal of Australia·David W JohnsonUNKNOWN Australasian Proteinuria Consensus Working Group
Sep 25, 2012·Journal of Internal Medicine·F Kronenberg, G Utermann
Aug 24, 2013·International Journal of Hypertension·Nicolás F RennaRoberto M Miatello
Jan 1, 2014·Journal of Internal Medicine·J C HopewellUNKNOWN PROCARDIS Consortium
Feb 18, 2014·Atherosclerosis·Paulo Caleb Junior Lima SantosAlexandre Costa Pereira
Apr 10, 2014·Lipids in Health and Disease·Matthew D AllardJiri Frohlich
Mar 24, 2015·Atherosclerosis·K HaralambosI F W McDowell
Citations
May 21, 2016·Nature Reviews. Endocrinology·Katrina L EllisGerald F Watts
Jun 2, 2016·The Lancet. Diabetes & Endocrinology·Raul D SantosUNKNOWN International Atherosclerosis Society Severe Familial Hypercholesterolemia Panel
Sep 12, 2016·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·D C ChanG F Watts
May 10, 2017·European Journal of Preventive Cardiology·Katrina L EllisGerald F Watts
Jun 24, 2017·European Journal of Preventive Cardiology·Ivan PećinŽeljko Reiner
Apr 1, 2018·Journal of Clinical Laboratory Analysis·Di SunJian-Jun Li
Feb 27, 2018·Clinical Cardiology·Katrina L EllisGerald F Watts
Feb 7, 2018·The Journal of Clinical Endocrinology and Metabolism·Dick C ChanGerald F Watts
Jun 8, 2018·Journal of Atherosclerosis and Thrombosis·Mariko Harada-ShibaUNKNOWN Working Group by Japan Atherosclerosis Society for Making Guidance of Familial Hypercholesterolemia
May 1, 2018·Current Opinion in Lipidology·Martine Paquette, Alexis Baass
Mar 26, 2016·Circulation. Cardiovascular Genetics·Emil M deGomaJoshua W Knowles
Aug 23, 2019·Clinical Cardiology·Di SunJian-Jun Li
Sep 2, 2020·Current Atherosclerosis Reports·Jing PangGerald F Watts
Feb 24, 2016·Journal of Atherosclerosis and Thrombosis·Jing PangGerald F Watts
Feb 3, 2020·Acta Diabetologica·Jun LyuQingbin Zhao
Feb 16, 2016·Journal of Atherosclerosis and Thrombosis·Miao HuBrian Tomlinson
Sep 2, 2016·The Medical Journal of Australia·Damon A Bell, Gerald F Watts
Mar 28, 2019·Expert Review of Cardiovascular Therapy·Katrina L EllisGerald F Watts
Jan 25, 2020·Nature Reviews. Cardiology·Gerald F WattsKausik K Ray
Oct 8, 2020·Current Opinion in Lipidology·Calvin YeangSotirios Tsimikas
Sep 3, 2020·Heart, Lung & Circulation·Jing PangUNKNOWN members of the FH Australasia Network Registry
Mar 7, 2021·Journal of Lipid Research·Kévin ChemelloDirk Blom
Apr 18, 2020·Heart, Lung & Circulation·Hnin P OoDavid L Hare
Mar 25, 2020·Trends in Cardiovascular Medicine·Vanessa BianconiUNKNOWN International Lipid Expert Panel (ILEP)
Nov 17, 2020·Heart, Lung & Circulation·Nick S R LanDamon A Bell
May 7, 2021·Clinical Cardiology·Anindita ChakrabortyGerald F Watts