Elevated lipoprotein(a) levels and small apo(a) isoforms are compatible with longevity: evidence from a large population of French centenarians

Atherosclerosis
J ThilletL Faure-Delanef

Abstract

Epidemiological studies have shown lipoprotein(a) (Lp(a)) to be an independent risk factor for cardiovascular disease. Lp(a) is a cholesterol-rich, low-density lipoprotein (LDL)-like particle to which a large glycoprotein, apolipoprotein(a) (apo(a)) is attached. Plasma Lp(a) levels are highly genetically determined and influenced to a minor degree by environmental factors. In an effort to determine whether Lp(a) might be associated with longevity, we have evaluated Lp(a) levels and apo(a) isoform sizes in a population of French centenarians (n = 109) compared to a control group (n = 227). The mean age of centenarians was 101.5 +/- 2.4 years while the control group was 39.4 +/- 7.2 years. Plasma levels of total cholesterol and triglyceride were within the normal range in both centenarian and control subjects. Lp(a) levels were higher in centenarians (both male and female) than in the normolipidemic control group (mean Lp(a) level = 0.33 +/- 0.42 and 0.22 +/- 0.27 mg/ml, respectively, P < 0.005). The distribution of apo(a) isoforms was significantly shifted towards small isoform size in the centenarian population as compared to the controls (54.4 and 41.4% of isoforms < or = 27 kringles (kr), respectively, P = 0.04). Nonetheless,...Continue Reading

References

Oct 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·C SandholzerG Utermann
Nov 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M CambillauM C Plainfosse
Jun 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·H J ParraG Luc
Mar 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J LoscalzoA M Scanu
Aug 1, 1987·The Journal of Clinical Investigation·G UtermannC Seitz
Jan 15, 1995·Circulation·M Dammerman, J L Breslow
Jan 1, 1994·Nature Genetics·F SchächterD Cohen
Sep 1, 1993·European Journal of Epidemiology·M CigoliniG Targher
Jan 1, 1996·Archives of Gerontology and Geriatrics·M MalaguarneraG Pistone

❮ Previous
Next ❯

Citations

Jul 3, 2002·Aging Clinical and Experimental Research·Bernard Jeune
Nov 10, 2007·Rejuvenation Research·Francesco PanzaVincenzo Solfrizzi
Sep 27, 2012·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Émilie MarrerMichel Velten
Mar 14, 2013·BioMed Research International·Michele MalaguarneraAlessandro Frigiola
Mar 7, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·V SchulterG M Kostner
Mar 30, 1999·Current Opinion in Lipidology·L Puckey, B Knight
Sep 21, 2005·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Miroslava ZamaklarTatjana Potpara
Dec 8, 2015·Journal of Lipid Research·Byambaa EnkhmaaLars Berglund
Aug 4, 1999·Current Opinion in Lipidology·H H Hobbs, A L White
May 10, 2002·Pediatric Transplantation·Uwe Querfeld, Friederike Wahn
Jul 8, 2005·The New England Journal of Medicine·Sotirios TsimikasPeter B Berger
Mar 12, 2003·Critical Reviews in Clinical Laboratory Sciences·Giuseppe Lippi, Giancesare Guidi
Sep 4, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Lars Berglund, Rajasekhar Ramakrishnan
Mar 16, 2005·Current Opinion in Lipidology·Jose M Ordovas, Vincent Mooser
Nov 3, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Guglielmina ChimientiGabriella Pepe
Oct 29, 2000·Experimental Gerontology·B T HeijmansP E Slagboom
Nov 18, 2006·Clinics in Laboratory Medicine·Erdembileg AnuuradLars Berglund
Apr 20, 2007·Cancer Treatment Reviews·Giuseppe LippiGian Cesare Guidi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.