Elevated Liver Biochemistries in Hospitalized Chinese Patients With Severe COVID-19: Systematic Review and Meta-analysis.

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Alexander J KovalicSanjaya K Satapathy

Abstract

Several recent studies have reported an abnormal liver chemistry profile among patients with coronavirus disease 2019 (COVID-19), although its clinical significance remains unknown. This systematic review and meta-analysis identified six studies of 586 patients delineating liver chemistries among patients with severe/critical illness versus mild cases of COVID-19 infection. Patients with severe/critical illness with COVID-19 infection have increased prevalence of coronary artery disease, cerebrovascular disease, and chronic obstructive pulmonary disease as compared with mild cases. A significant association between severe/critical COVID-19 infections with elevations in aspartate aminotransferase (pooled mean difference [MD], 11.70 U/L; 95% confidence interval [CI], 2.97, 20.43; P = 0.009), elevated total bilirubin (pooled MD, 0.14 mg/dL; 95% CI, 0.06, 0.22; P = 0.0005), and decreased albumin (pooled MD, -0.68 g/L; 95% CI, -0.81, -0.55; P < 0.00001) was noted. There was also a trend toward elevated alanine aminotransferase levels among these severe cases (pooled MD, 8.84 U/L; 95% CI, -2.28, 19.97; P = 0.12); however, this did not reach statistical significance. More severe/critically ill cases were associated with leukocytosis, ...Continue Reading

References

Apr 13, 1991·Lancet·P J EasterbrookD R Matthews
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Apr 21, 2005·BMC Medical Research Methodology·Stela Pudar HozoIztok Hozo
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Mar 13, 2013·Prevention Science : the Official Journal of the Society for Prevention Research·Michael Borenstein, Julian P T Higgins
Sep 30, 2016·Statistical Methods in Medical Research·Dehui LuoTiejun Tong
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Feb 23, 2020·The Lancet. Respiratory Medicine·Zhe XuFu-Sheng Wang
Mar 1, 2020·International Journal of Surgery·Catrin SohrabiRiaz Agha
Mar 8, 2020·The Lancet. Gastroenterology & Hepatology·Chao ZhangFu-Sheng Wang
Mar 15, 2020·The Lancet. Gastroenterology & Hepatology·Ren MaoUNKNOWN Chinese IBD Quality Care Evaluation Center Committee
Mar 22, 2020·Journal of Medical Virology·Suxin WanRuishan Yang
Mar 25, 2020·International Journal of Antimicrobial Agents·Philippe GautretDidier Raoult
Apr 7, 2020·JAMA : the Journal of the American Medical Association·Giacomo GrasselliUNKNOWN COVID-19 Lombardy ICU Network
Apr 11, 2020·The New England Journal of Medicine·Jonathan GreinTimothy Flanigan
Apr 17, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Oren K FixRaymond T Chung
Apr 23, 2020·JAMA : the Journal of the American Medical Association·Safiya RichardsonTheodoros P Zanos
Apr 28, 2020·Clinical Drug Investigation·Shengyu ZhangZhigang Qi
May 28, 2020·The New England Journal of Medicine·Jason D GoldmanUNKNOWN GS-US-540-5773 Investigators

❮ Previous
Next ❯

Citations

Sep 3, 2020·Digestive Diseases and Sciences·Andrew M Moon, A Sidney Barritt
Oct 6, 2020·Digestive Diseases and Sciences·Paul J ThuluvathSanjaya K Satapathy
Aug 20, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Elena AloisioMauro Panteghini
Aug 28, 2021·Journal of Clinical and Translational Hepatology·Deepak MadhuAnoop Saraya

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.