Elevated markers of thrombo-inflammatory activation predict outcome in patients with cardiovascular comorbidities and COVID-19 disease: insights from the LEOSS registry.

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
Sebastian CremerLEOSS Study group

Abstract

SARS-CoV-2 infection is associated with adverse outcomes in patients with cardiovascular disease. Here, we analyzed whether specific biomarkers predict the clinical course of COVID-19 in patients with cardiovascular comorbidities. We enrolled 2147 patients with SARS-CoV-2 infection which were included in the Lean European Open Survey on SARS-CoV‑2 (LEOSS)-registry from March to June 2020. Clinical data and laboratory values were collected and compared between patients with and without cardiovascular comorbidities in different clinical stages of the disease. Predictors for mortality were calculated using multivariate regression analysis. We show that patients with cardiovascular comorbidities display significantly higher markers of myocardial injury and thrombo-inflammatory activation already in the uncomplicated phase of COVID-19. In multivariate analysis, elevated levels of troponin [OR 1.54; (95% CI 1.22-1.96), p < 0.001)], IL-6 [OR 1.69 (95% CI 1.26-2.27), p < 0.013)], and CRP [OR 1.32; (95% CI 1.1-1.58), p < 0.003)] were predictors of mortality in patients with COVID-19. Patients with cardiovascular comorbidities show elevated markers of thrombo-inflammatory activation and myocardial injury, which predict mortality, already...Continue Reading

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Citations

Apr 22, 2021·Journal of Translational Autoimmunity·Gerd WallukatJohannes Müller
Jul 17, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Somaya Albhaisi, Richard P Wenzel
Aug 28, 2021·Frontiers in Immunology·Ying-Yi LuanYong-Ming Yao
Sep 22, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Marina RiederDaniel Duerschmied

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BETA
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SPSS

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