PMID: 9649085Jul 2, 1998Paper

Elevated maternal serum relaxin concentrations throughout pregnancy in singleton gestations after superovulation

Obstetrics and Gynecology
T I MushayandebvuG Weiss

Abstract

To test the hypothesis that superovulation results in elevated maternal circulating relaxin concentrations throughout the second and third trimesters of pregnancy, independent of the pattern of hCG secretion. Two groups of women with singleton gestations were studied: a group of nine women who achieved pregnancy after stimulation with human menopausal gonadotropin and a group of six women who achieved pregnancy without prior stimulation. Peripheral blood samples were drawn approximately every 5 weeks throughout the second and third trimesters. Serum relaxin concentrations were measured using a human relaxin-specific enzyme-linked immunosorbent assay; hCG was measured by an immunofluorometric assay. The stimulated group had significantly higher relaxin levels throughout pregnancy (P=.007, multivariate analysis of variance) than did nonstimulated controls. The mean relaxin level in stimulated patients was 1.78 ng/mL (95% confidence interval [CI] 1.5, 2.17) and in nonstimulated subjects the level was 0.73 ng/mL (95% CI 0.59, 1.25). Spline fits demonstrated that stimulated patients had higher relaxin levels throughout the second and third trimesters. There was no significant difference in hCG concentrations between the two groups (...Continue Reading

References

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Citations

Nov 5, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Nikolaos VrachnisZoe Iliodromiti
Mar 6, 2012·Placenta·J S HortonG D Bryant-Greenwood
Apr 3, 2012·Fertility and Sterility·Stephanie A Beall, Alan DeCherney
Jul 7, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sarah D McDonaldUNKNOWN Knowledge Synthesis Group
Jun 16, 2005·Annals of the New York Academy of Sciences·Gerson Weiss, Laura T Goldsmith
May 24, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Qingzhi HouXiaobo Yang
Aug 21, 2013·The Cochrane Database of Systematic Reviews·Emily BainCaroline A Crowther
Jul 8, 2011·Biology of Reproduction·J S HortonG D Bryant-Greenwood
Jan 14, 2003·Experimental Biology and Medicine·Paul G WhittakerBernard G Steinetz
Mar 23, 2011·Archives of Gynecology and Obstetrics·Vlatka Tomic, Jozo Tomic
Aug 14, 2019·American Journal of Physiology. Endocrinology and Metabolism·Kirk P ConradMaureen Keller-Wood
Dec 20, 2020·Molecular and Cellular Endocrinology·Rosalieke E WiegelA H Jan Danser
Mar 23, 2021·Human Reproduction Update·María M PereiraJerome F Strauss
Feb 25, 2015·Fertility and Sterility·Galit Levi DunietzMichael P Diamond
Apr 21, 2021·Molecular and Cellular Endocrinology·Rosalieke E WiegelA H Jan Danser

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