Elevated matrix metalloproteinase-9 and degradation of perineuronal nets in cerebrocortical multiple sclerosis plaques.

Journal of Neuropathology and Experimental Neurology
Elizabeth GraySeth Love

Abstract

Matrix metalloproteinases (MMPs) degrade extracellular matrix; MMP activity, particularly of MMP-9, is elevated in the white matter in multiple sclerosis (MS) patients. The cerebral cortical extracellular matrix includes perineuronal nets (PNs) that surround parvalbumin-positive neurons (PV-positive neurons) and are important for their function. We measured active and total MMP-9 levels in postmortem homogenates of demyelinated and nondemyelinated cerebral cortical regions from 9MS and 7 control cases and assessed Wisteria floribunda agglutin (WFA)-positive PNs in paraffin sections from 15 MS and 6 controls and PV-positive neurons in sections from 26 MS and 6 controls. Active MMP-9 levels were higher in demyelinated than in nondemyelinated or control cortex (p < 0.05). The area fraction positive for WFA was lower in demyelinated than nondemyelinated MS or control cortex; the latter difference was significant (p < 0.05). Most PV-positive neurons in demyelinated but not intact cortex lackeda PN, and some showed perikaryal phosphorylated neurofilament protein accumulation. Loss of WFA-labeled PNs was not associated with reduced PV-positive neurons numbers. Thus, elevated MMP-9 in cortical plaques is associated with loss of PNs; PV...Continue Reading

References

Sep 3, 1990·Brain Research·P KlosenP van den Bosch de Aguilar
Jan 1, 1990·Cold Spring Harbor Symposia on Quantitative Biology·S HockfieldH Fryer
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·G J Peppin, S J Weiss
Jan 1, 1994·Brain Research. Brain Research Reviews·M R Celio, I Blümcke
May 13, 1996·Brain Research·G BrücknerK Brauer
Mar 1, 1996·Journal of Neuropathology and Experimental Neurology·A Maeda, R A Sobel
May 1, 1996·Journal of Neurocytology·G BrücknerK Brauer
Nov 19, 1997·Neuropathology and Applied Neurobiology·D C AnthonyV H Perry
Jan 28, 1998·Acta Neuropathologica·J A CossinsC J De Groot
Jan 9, 1999·Trends in Neurosciences·M R CelioL Vitellaro-Zuccarello
Jul 27, 1999·Neuropathology and Applied Neurobiology·N J GutowskiM L Cuzner
Nov 15, 2000·The Journal of Comparative Neurology·G BrücknerM Schachner
May 15, 2002·Brain Research. Molecular Brain Research·E M MuirJ H Rogers
Jul 18, 2002·Multiple Sclerosis : Clinical and Laboratory Research·G M LiuzziP Riccio
Nov 9, 2002·Science·Kevin Fox, Bruce Caterson
Nov 9, 2002·Science·Tommaso PizzorussoLamberto Maffei
May 14, 2003·Journal of Neuroimmunology·Catharina M P VosHelga E de Vries
Aug 7, 2003·Biochemical and Biophysical Research Communications·Marta TothRafael Fridman
Jul 13, 2004·Experimental Neurology·Markus MorawskiThomas Arendt
Sep 15, 2004·Current Opinion in Cell Biology·Joni D Mott, Zena Werb

❮ Previous
Next ❯

Citations

Feb 23, 2012·Analytical and Bioanalytical Chemistry·Mohamed-Anis AlouiniGérard Déléris
Sep 5, 2013·Acta neurologica Belgica·Mohammad A JavaidZeeshan Sheikh
Jul 23, 2013·Molecular Neurobiology·Arash NazeriAmit Bar-Or
Apr 27, 2016·Biological Psychiatry·Byron K Y BitanihirweTsung-Ung W Woo
Jul 2, 2009·Acta Neurologica Scandinavica. Supplementum·L Bø
Apr 9, 2014·Neuroscience and Biobehavioral Reviews·Byron K Y Bitanihirwe, Tsung-Ung W Woo
Feb 24, 2015·Nature Reviews. Neuroscience·Massimiliano CalabreseRoland Martin
Apr 11, 2017·Journal of Medicinal Chemistry·Manishabrata BhowmickGregg B Fields
Aug 31, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·N V Khachanova
Aug 30, 2013·Nature Reviews. Neuroscience·Lorraine W LauV Wee Yong
May 18, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Francesca BagnatoUNKNOWN NAIMS Cooperative
Jul 1, 2020·The European Journal of Neuroscience·Philipp UlbrichAlexander Dityatev
Jun 27, 2020·Journal of Biomedical Science·Wen-Wei LinTian-Lu Cheng
Oct 18, 2020·The Journal of Comparative Neurology·Jacob A EdwardsKim L Hoke
Dec 4, 2020·International Journal of Molecular Sciences·Jean-Philippe Dales, Sophie Desplat-Jégo
Feb 13, 2021·The Journal of Comparative Neurology·Elise M AronitzKevin R Duffy
Feb 1, 2020·Schizophrenia Research·Byron K Y Bitanihirwe, Tsung-Ung W Woo
Mar 7, 2021·International Journal of Molecular Sciences·Daniela Carulli, Joost Verhaagen
Aug 21, 2021·Cellular & Molecular Immunology·Joshua D CrapserKim N Green

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.