Elevated medial temporal lobe and pervasive brain tau-PET signal in normal participants

Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Val J LoweClifford R Jack

Abstract

Medial temporal lobe (MTL) uptake on tau-positron emission tomography (PET) is seen not only in Alzheimer's disease (AD) dementia but also in the aging population. The relationship of these findings to the development of AD dementia needs to be better understood. Tau-PET with AV-1451 was performed on 576 cognitively unimpaired (CU) participants aged 50-94 years. The number of CUs with and without abnormal MTL regions and those with or without extra-MTL abnormalities was determined. Left and right regions were compared within each subject. Of CUs, 58% (334/576) had abnormal tau-PET findings. MTL abnormalities were present in 41% (238/576) of subjects. MTL tau-PET signal is often associated with abnormal extra-MTL tau-PET signal in CU participants and may represent neurofibrillary tangle development that could identify participants most likely to develop AD dementia. Tau-PET signal exclusively outside of the MTL is seen in 17% of CU participants and could be the initial findings in participants in different AD dementia pathways. Significant (P < .001) differences in tau-standardized uptake value ratio between sides were noted in 26 of 41 examined brain regions implicating further study of side-specific deficits.

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Jan 1, 1990·Epidemiology·K J Rothman
Jan 1, 1996·European Archives of Psychiatry and Clinical Neuroscience·H J GertzC M Wischik
May 1, 1997·Neurobiology of Aging·C DuyckaertsJ J Hauw
Jul 1, 1997·Neurobiology of Aging·H Braak, E Braak
Jul 1, 1997·Neurobiology of Aging·W SilvermanJ Wegiel
Jul 12, 2002·Annals of Neurology·Kathryn P RileyWilliam R Markesbery
Jun 16, 2005·NeuroImage·John Ashburner, Karl J Friston
Apr 8, 2011·Journal of Alzheimer's Disease : JAD·Erin L AbnerPeter T Nelson
Jan 10, 2012·Cold Spring Harbor Perspectives in Medicine·Alberto Serrano-PozoBradley T Hyman
Jan 24, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Bradley T HymanThomas J Montine
Apr 11, 2012·Journal of Neuropathology and Experimental Neurology·Peter T NelsonThomas G Beach
Feb 16, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Chun-Fang XiaHartmuth C Kolb
Apr 8, 2014·Neurology·Clifford R JackRonald C Petersen
May 6, 2014·Neurology·Val J LoweRonald C Petersen
Jun 26, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Hiroki HashimotoMing-Rong Zhang
Nov 27, 2014·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Eduardo Rigon ZimmerPedro Rosa-Neto
Oct 28, 2015·Annals of Neurology·Keith A JohnsonReisa Sperling
Mar 5, 2016·Neuron·Michael SchöllWilliam J Jagust
Mar 11, 2016·Brain : a Journal of Neurology·Rik OssenkoppeleGil D Rabinovici
May 14, 2016·Science Translational Medicine·Matthew R BrierBeau M Ances
Jun 15, 2016·Acta Neuropathologica Communications·Val J LoweMelissa E Murray
Oct 30, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Clifford R JackRonald C Petersen
Jan 13, 2017·Brain : a Journal of Neurology·Michael J PontecorvoUNKNOWN 18F-AV-1451-A05 investigators
Dec 12, 2017·Brain : a Journal of Neurology·Val J LoweClifford R Jack

❮ Previous
Next ❯

Citations

Feb 16, 2019·Acta Neuropathologica Communications·Santosh JadhavNorbert Zilka
Feb 14, 2019·Brain : a Journal of Neurology·David S KnopmanClifford R Jack
Oct 20, 2020·JAMA Neurology·David S KnopmanUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jan 6, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Karine ProvostUNKNOWN Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Jan 15, 2021·Clinical Nuclear Medicine·Olga G JamesTerence Z Wong

❮ Previous
Next ❯

Software Mentioned

SPM5

Related Concepts

Related Feeds

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Aging Epidemiology

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Related Papers

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics
Akihiko Takashima
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Prashanthi VemuriClifford R Jack
Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
Caterina RosanoLewis H Kuller
© 2022 Meta ULC. All rights reserved