Elevated mid-trimester amniotic fluid ADAM-8 concentrations as a potential risk factor for preterm delivery

Journal of the Society for Gynecologic Investigation
Nikolaos VrachnisGeorge Creatsas

Abstract

To determine during mid-trimester amniocentesis if elevated concentrations of ADAM-8 (A Disintegrin And Metalloprotease 8) and/or cortisol can recognize women at risk for spontaneous preterm delivery. The study involved 312 women who underwent mid-trimester amniocentesis. Thirteen patients, who progressed to preterm delivery, were matched with 21 controls for age, parity, gestational age at amniocentesis, and year of amniocentesis. ADAM-8 and cortisol levels were measured by enzyme-linked immunosorbent assay and radioimmunoassay, respectively. ADAM-8 mean amniotic fluid concentrations were significantly higher in women with preterm delivery than in women delivering at term (mean 1213.9 [SE 96.7] pg/mL [range, 780 to 1854 pg/mL] vs mean 937.2 [SE 50.3] pg/mL [range, 486 to 1508 pg/mL], P < .02). Amniotic fluid ADAM-8 concentrations higher than 1149 pg/mL had the highest specificity and odds ratio (OR) in the identification of the women with increased risk for preterm delivery (sensitivity 61.5%; specificity 81.7%; OR, 9.6 [95% confidence interval (CI), 1.8 to 50.3]). Women with preterm delivery had suggestively higher amniotic fluid concentrations of cortisol (mean 1.3 [SE 0.2] microg/dL [range, 0.4 to 2.2 microg/dL]) than women...Continue Reading

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Citations

Nov 7, 2009·Mediators of Inflammation·C IavazzoA Malamitsi-Puchner
Oct 27, 2011·Clinical & Developmental Immunology·Nikolaos VrachnisZoe Iliodromiti
Jul 22, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Michela TorricelliFelice Petraglia
Oct 5, 2007·Journal of Reproductive Immunology·Devrim SezenSteven S Witkin
Feb 20, 2007·Annals of the New York Academy of Sciences·Ariadne Malamitsi-PuchnerDimitrios Hassiakos
Jun 28, 2013·The Journal of Obstetrics and Gynaecology Research·Abdullah KaraerSenem Arda Duz
Sep 16, 2010·Annals of the New York Academy of Sciences·N VrachnisG Creatsas
Apr 29, 2009·Expert Opinion on Therapeutic Targets·Martin D Knolle, Caroline A Owen
Jan 21, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Nikolaos VrachnisZoi Iliodromiti

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