PMID: 8606882Nov 1, 1995Paper

Elevated mid-trimester hCG and maternal lupus anticoagulant

Prenatal Diagnosis
F ClarkP C O'Leary

Abstract

An association is described between women with lupus anticoagulant and abnormal prenatal serum screening results. Three cases of positive second-trimester serum screening for Down syndrome, with karyotypically normal fetuses, in women demonstrated to have lupus anticoagulant are presented. Serum screening positivity was principally due to a disproportionately elevated maternal serum human chorionic gonadotrophin (hCG) level. In each case, early, severe intrauterine growth restriction was documented, with only one fetus surviving the neonatal period. As maternal lupus anticoagulant may have a profoundly adverse effect on the course of pregnancy, we suggest that an elevated hCG level on prenatal screening prompt consideration of maternal lupus anticoagulant testing if ultrasonography demonstrates an otherwise normal singleton gestation and the fetal karyotype is normal.

References

Nov 1, 1992·American Journal of Medical Genetics·C P GravettM G Gravett
Jan 1, 1991·Reproduction, Fertility, and Development·T Y Khong, I H Sawyer
Apr 1, 1985·British Journal of Obstetrics and Gynaecology·B N WaltersM De Swiet
Nov 21, 1985·The New England Journal of Medicine·D W BranchE Hershgold
May 1, 1994·Prenatal Diagnosis·S Knowles, P Flett
Oct 1, 1993·British Journal of Obstetrics and Gynaecology·N S PattisonW S Butler
Oct 1, 1993·American Journal of Obstetrics and Gynecology·T K SorensenD E Hickok

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Citations

Mar 1, 1997·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·L S Onderoğlu, A Kabukçu
Mar 5, 2008·Prenatal Diagnosis·Murat MuhcuYusuf Ziya Yergok
Feb 10, 2021·Clinical Rheumatology·N Martínez-SánchezJ L Bartha

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