Elevated midlife blood pressure increases stroke risk in elderly persons: the Framingham Study

Archives of Internal Medicine
Sudha SeshadriR B D'Agostino

Abstract

Stroke risk predictions are traditionally based on current blood pressure (BP). The potential impact of a subject's past BP experience (antecedent BP) is unknown. We assessed the incremental impact of antecedent BP on the risk of ischemic stroke. A total of 5197 stroke-free subjects (2330 men) in the community-based Framingham Study cohort were enrolled from September 29, 1948, to April 25, 1953, and followed up to December 31, 1998. We determined the 10-year risk of completed initial ischemic stroke for 60-, 70-, and 80-year-old subjects as a function of their current BP (at baseline), recent antecedent BP (average of readings at biennial examinations 1-9 years before baseline), and remote antecedent BP (average at biennial examinations 10-19 years earlier), with adjustment for smoking and diabetes mellitus. Models incorporating antecedent BP were also adjusted for baseline BP. The effect of each BP component (systolic BP, diastolic BP, and pulse pressure) was assessed separately. Four hundred ninety-one ischemic strokes (209 in men) were observed in eligible subjects. The antecedent BP influenced the 10-year stroke risk at the age of 60 years (relative risk per SD increment of recent antecedent systolic BP: women, 1.68 [95% c...Continue Reading

Citations

Jun 28, 2014·The Canadian Journal of Cardiology·Jessica GorguiStella S Daskalopoulou
Jul 16, 2008·Annals of Internal Medicine·Mark J PletcherStephen B Hulley
Aug 2, 2011·American Journal of Epidemiology·George HowardHemant K Tiwari
Oct 26, 2013·Current Hypertension Reports·Jolanta MalyszkoMaciej Banach
Feb 3, 2005·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·U E K Schnurrbusch, S Wolf
Oct 2, 2009·Journal of the American Geriatrics Society·Lucy Y WangGe Li
Mar 29, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J-H ParkJ-K Roh
Nov 5, 2010·Journal of the American Geriatrics Society·Margaret Kelly-Hayes
May 3, 2016·Journal of Mid-life Health·Supreet Khare
Sep 6, 2005·Primary Care·Michael MaddensAyham Ashkar
Jun 20, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Jinlei LiRhoda Au
Feb 6, 2008·Hypertension·Stefan KnechtE Bernd Ringelstein
Jan 7, 2006·Stroke; a Journal of Cerebral Circulation·Sudha SeshadriPhilip A Wolf
Jan 5, 2002·Circulation·Ramachandran S VasanUNKNOWN Framingham Heart Study
May 27, 2006·Stroke; a Journal of Cerebral Circulation·Per HarmsenLars Wilhelmsen
Mar 1, 2012·Stroke; a Journal of Cerebral Circulation·Dominique A CadilhacHelen M Dewey
Jun 4, 2005·Stroke; a Journal of Cerebral Circulation·Haralampos J MilionisMoses S Elisaf
Sep 23, 2008·Anesthesia and Analgesia·Manuel L FontesUNKNOWN Ischemia Research and Education Foundation (IREF) Investigators
Apr 7, 2010·Nature Reviews. Neurology·Ruo-Li ChenAlastair M Buchan
Feb 18, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ikuno TakahashiMasayasu Matsumoto
Apr 17, 2003·Current Opinion in Nephrology and Hypertension·Michael H Freitag, Ramachandran S Vasan
Mar 26, 2013·Global Heart·Jose R Romero, Philip A Wolf
Feb 23, 2020·Annals of Medicine·Joel NuotioTeemu Niiranen
Jul 18, 2020·Journal of Clinical Medicine·Raúl Soto-CámaraRemedios López-Liria
Jan 31, 2013·Echocardiography·Ahmed AljizeeriTeresa S M Tsang
Nov 16, 2018·JMIR MHealth and UHealth·Hussein JamaladinMarleen Mhj van Gelder
Jul 7, 2020·Journal of the American Heart Association·Dipender GillMartin Dichgans
Jul 20, 2019·Journal of the American College of Cardiology·Yiyi ZhangAndrew E Moran
Aug 17, 2021·Kardiologiia·O D OstroumovaA A Kirichenko
Apr 16, 2011·Journal of Cardiothoracic and Vascular Anesthesia·Solomon Aronson, Joseph Varon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

© 2021 Meta ULC. All rights reserved