Elevated midtrimester maternal serum hCG in chromosomally normal pregnancies is associated with preeclampsia and velamentous umbilical cord insertion

American Journal of Perinatology
S HeinonenS Saarikoski

Abstract

This study was undertaken to determine whether patients with unexplained, elevated second-trimester maternal serum human chorionic gonadotropin (hCG) concentrations are at increased risk of adverse pregnancy outcome. In a retrospective study, perinatal outcomes of 355 patients showing elevated second-trimester maternal serum hCG concentrations (> or = 2.0 multiples of median) were compared with those of patients from the same clinic showing normal values (N = 4935), using multiple regression analysis. The effects of variables such as socioeconomic status on pregnancy outcome were taken into account. Between the study subjects and controls, statistically significant differences were observed as regards low birthweight (odds ratio [OR] 1.56, 95% confidence interval [CI]: 1.00-2.44) and intrauterine growth retardation (OR 1.46, 95% CI: 1.03-2.06). Differences in the frequencies of preterm delivery, fetal/perinatal death, fetal distress, or admission to a specific infant care unit were not statistically significant. Preeclampsia (OR 1.76, 95% CI: 1.16-2.70) and velamentous umbilical cord insertion (OR 2.62, 95% CI: 1.47-4.69) were particularly involved in the pathophysiology. Elevated maternal serum hCG concentrations were associat...Continue Reading

Citations

Dec 30, 1999·The New England Journal of Medicine·D L WaltonC J Colby
Sep 23, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·A Conde-AgudeloA T Papageorghiou
Nov 3, 2005·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Reli HershkovitzJohn Kingdom
Dec 6, 2005·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J Roiz-HernándezM Fernández-Mejía
May 4, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Eita Goto
Jun 25, 2015·Clinical Medicine Insights. Reproductive Health·Anna YliniemiMarkku Ryynanen
Jul 11, 2007·Prenatal Diagnosis·Ramesh GanapathyPaul Bassett
Apr 12, 2002·Endocrine Reviews·Fernando M ReisFelice Petraglia
Sep 7, 1999·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·M EzimokhaiL Thomas
Nov 28, 2019·ACS Applied Materials & Interfaces·Zhenwei MaChristopher Moraes

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