Elevated mitochondrial superoxide contributes to enhanced chemoreflex in heart failure rabbits.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Yanfeng DingHarold D Schultz

Abstract

Peripheral chemoreflex sensitivity is enhanced in both clinical and experimental chronic heart failure (CHF). Here we investigated the role of manganese superoxide dismutase (MnSOD), the SOD isoform specially targeted to mitochondria, and mitochondrial superoxide levels in the enhanced chemoreceptor activity and function of the carotid body (CB) in CHF rabbits. CHF suppressed MnSOD protein expression and elevated mitochondrial superoxide levels in CB compared with that in sham CB. Adenovirus (Ad) MnSOD (1 x 10(8) plaque-forming units/ml) gene transfer selectively to the CBs normalized mitochondrial superoxide levels in glomus cells from CHF CB. In addition, Ad MnSOD reduced the elevation of superoxide level in CB tissue from CHF rabbits. Ad MnSOD significantly increased MnSOD expression in CHF CBs and normalized the baseline renal sympathetic nerve activity and the response of renal sympathetic nerve activity to hypoxia in CHF rabbits. Ad MnSOD decreased baseline single-fiber discharge from CB chemoreceptors compared with Ad Empty (6.3 + or - 1.5 vs. 12.7 + or - 1.4 imp/s at approximately 100-Torr Po(2), P < 0.05) and in response to hypoxia (20.5 + or - 1.8 vs. 32.6 + or - 1.4 imp/s at approximately 40-Torr Po(2), P < 0.05) in ...Continue Reading

References

May 1, 1995·Progress in Cardiovascular Diseases·I H ZuckerK P Patel
Jan 1, 1994·Advances in Experimental Medicine and Biology·N R Prabhakar
Oct 1, 1994·Physiological Reviews·C GonzalezR Rigual
Oct 1, 1993·Journal of the American College of Cardiology·J S Floras
Oct 1, 1996·American Heart Journal·S S ChughA J Coats
Dec 31, 1997·The American Journal of Cardiology·M EslerG Jennings
May 8, 2000·Journal of Applied Physiology·N S Chandel, P T Schumacker
Feb 22, 2001·Annual Review of Physiology·J Lopez-BarneoP Ortega-Sáenz
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·M ZanettiT O'Brien
Jun 23, 2001·Circulation Research·G B WaypaP T Schumacker
Aug 17, 2001·The Journal of Biological Chemistry·A Okado-Matsumoto, I Fridovich
Nov 29, 2002·Circulation Research·Matthew C ZimmermanRobin L Davisson
Feb 11, 2004·Progress in Biophysics and Molecular Biology·Irving H ZuckerKaushik P Patel
Oct 18, 2005·Heart Failure Reviews·H D Schultz, S Y Sun
Nov 12, 2005·The New England Journal of Medicine·E Kenneth WeirStephen L Archer
Oct 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kristine M RobinsonJoseph S Beckman
Nov 23, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rajamanickam BaskarPhilip Keith Moore
Mar 31, 2007·Journal of Neurochemistry·Matthew C ZimmermanShawn W Flanagan
Nov 27, 2007·Biochimica Et Biophysica Acta·Jeremy P T Ward
Mar 14, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shih-Yin ChenJanice Y Chou
Jun 10, 2008·Nature Protocols·Kristine M RobinsonJoseph S Beckman
Dec 9, 2008·The Biochemical Journal·Michael P Murphy
Dec 17, 2008·Annals of the New York Academy of Sciences·Anatoly A Starkov
Dec 19, 2008·Cardiovascular Research·Yanfeng DingHarold D Schultz
May 12, 2009·The Medical Clinics of North America·David G Harrison, Maria Carolina Gongora
May 12, 2009·Free Radical Biology & Medicine·Alicia J KowaltowskiAnibal E Vercesi
Sep 1, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Irving H ZuckerLie Gao
Nov 17, 2010·The Journal of Physiology·Yanfeng DingHarold D Schultz

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Citations

Apr 3, 2012·Antioxidants & Redox Signaling·Kaushik P Patel, Harold D Schultz
May 13, 2014·BioMed Research International·Antonio C L NobregaAntonio Crisafulli
Jul 5, 2013·Current Hypertension Reports·Harold D SchultzRodrigo Del Rio
Nov 24, 2011·Heart Failure Clinics·Irving H ZuckerHarold D Schultz
Jan 19, 2011·Current Opinion in Pharmacology·Harold D Schultz
Aug 31, 2010·Respiratory Physiology & Neurobiology·E Kenneth Weir, Stephen L Archer
Aug 17, 2010·Respiratory Physiology & Neurobiology·Navdeep S Chandel
Jan 19, 2016·BioMed Research International·David C AndradeRodrigo Del Rio
Nov 17, 2010·The Journal of Physiology·Yanfeng DingHarold D Schultz
Nov 16, 2014·Experimental Physiology·Harold D SchultzRodrigo Del Rio
Feb 22, 2014·Autonomic Neuroscience : Basic & Clinical·Adil Z SolaimanKevin D Monahan
Jul 31, 2012·Respiratory Physiology & Neurobiology·Harold D SchultzNoah J Marcus
Aug 6, 2013·Autonomic Neuroscience : Basic & Clinical·João Paulo J SabinoRubens Fazan
May 25, 2016·The Journal of Physiology·Camilo ToledoRodrigo Del Rio
Feb 15, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Irving H ZuckerHanjun Wang
Oct 17, 2019·Annual Review of Physiology·Patricia Ortega-Sáenz, José López-Barneo
Aug 16, 2017·Scientific Reports·Rodrigo Del RioHarold D Schultz
Mar 28, 2020·Oxidative Medicine and Cellular Longevity·Sergio Rius-PérezSalvador Pérez
Apr 5, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Erin G RosenbaughMatthew C Zimmerman
Jan 20, 2022·Antioxidants & Redox Signaling·Lin GaoJosé López Barneo

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