Elevated Myo-Inositol, Choline, and Glutamate Levels in the Associative Striatum of Antipsychotic-Naive Patients With First-Episode Psychosis: A Proton Magnetic Resonance Spectroscopy Study With Implications for Glial Dysfunction

Schizophrenia Bulletin
Eric PlitmanAriel Graff-Guerrero

Abstract

Glial disturbances are highly implicated in the pathophysiology of schizophrenia and may be linked with glutamatergic dysregulation. Myo-inositol (mI), a putative marker of glial cells, and choline (Cho), representative of membrane turnover, are both present in larger concentrations within glial cells than in neurons, and their elevation is often interpreted to reflect glial activation. Proton magnetic resonance spectroscopy ((1)H-MRS) allows for the evaluation of mI, Cho, glutamate, glutamate + glutamine (Glx), and N-acetylaspartate (NAA). A collective investigation of these measures in antipsychotic-naive patients experiencing their first nonaffective episode of psychosis (FEP) can improve the understanding of glial dysfunction and its implications in the early stages of schizophrenia. 3-Tesla (1)H-MRS (echo time = 35 ms) was performed in 60 antipsychotic-naive patients with FEP and 60 age- and sex-matched healthy controls. mI, Cho, glutamate, Glx, and NAA were estimated using LCModel and corrected for cerebrospinal fluid composition within the voxel. mI, Cho, and glutamate were elevated in the FEP group. After correction for multiple comparisons, mI positively correlated with grandiosity. The relationships between mI and glu...Continue Reading

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Citations

Jun 9, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eric PlitmanAriel Graff-Guerrero
Jun 18, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Andrea SchmittUNKNOWN WFSBP Task Force on Biological Markers
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Sep 6, 2019·Psychopharmacology·Alice Egerton
Feb 12, 2017·Schizophrenia Bulletin·Eric PlitmanAriel Graff-Guerrero
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Feb 15, 2019·Frontiers in Human Neuroscience·Dohyun KimBumseok Jeong
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May 14, 2020·Molecular Neuropsychiatry·Caren J BlackerMarin Veldic

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