Elevated Neurokinin 1-Receptor Expression in uterine products of conception is associated with first trimester Miscarriages

BioRxiv : the Preprint Server for Biology
Riffat MehboobJaved Akram

Abstract

Background: Miscarriage is a common complication of early pregnancy, mostly occurring in first trimester. However, the etiological factors, prognostic and diagnostic biomarkers are not well known. Neurokinin 1 Receptor is a receptor of tachykinin peptide, Substance P and has a role in various pathological conditions, cancers but its association with miscarriages and significance as a clinicopathological parameter is not studied. Accordingly, the present study aimed to clarify the localization and expression for NK1R in human retained products of conception. Role of NK1R is not known in miscarriages. Materials and Methods: NK1R expression was assessed in products of conception by immunohistochemistry. Protein expression was evaluated using the nuclear labelling index. Results: Ten human products of conception tissues were studied by immunohistochemistry to demonstrate the localization of NK1R. The expression of NK1R protein was high in all the cases of POCs. NK1R expression showed no notable differences among different cases of miscarriages irrespective of the mothers age and gestational age at which the event occurred. Conclusions: Expression of NK-1R was similar in all the cases and it was intense. It shows that dysregulation ...Continue Reading

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