Elevated Oxidative Stress and Inflammation in Hypothalamic Paraventricular Nucleus Are Associated With Sympathetic Excitation and Hypertension in Rats Exposed to Chronic Intermittent Hypoxia

Frontiers in Physiology
Tiejun LiBaogang Wu

Abstract

Obstructive sleep apnea (OSA), characterized by recurrent collapse of the upper airway during sleep leading to chronic intermittent hypoxia (CIH), is an independent risk factor for hypertension. Sympathetic excitation has been shown to play a major role in the pathogenesis of OSA-associated hypertension. Accumulating evidence indicates that oxidative stress and inflammation in the hypothalamic paraventricular nucleus (PVN), a critical cardiovascular and autonomic center, mediate sympathetic excitation in many cardiovascular diseases. Here we tested the hypothesis that CIH elevates oxidative stress and inflammation in the PVN, which might be associated with sympathetic excitation and increased blood pressure in a rat model of CIH that mimics the oxygen profile in patients with OSA. Sprague-Dawley rats were pretreated with intracerebroventricular (ICV) infusion of vehicle or superoxide scavenger tempol, and then exposed to control or CIH for 7 days. Compared with control+vehicle rats, CIH+vehicle rats exhibited increased blood pressure, and increased sympathetic drive as indicated by the blood pressure response to ganglionic blockade and plasma norepinephrine levels. Pretreatment with ICV tempol prevented CIH-induced increases in...Continue Reading

References

Jul 1, 1993·Frontiers in Neuroendocrinology·G E HoffmanJ G Verbalis
Feb 1, 1997·Physiology & Behavior·Y F DuanN Schneiderman
Jan 12, 2001·Clinical and Experimental Pharmacology & Physiology·E Badoer
May 28, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Maram K ReddyHarold D Schultz
Sep 15, 2005·Hypertension·Carmen Hinojosa-Laborde, Steven W Mifflin
Apr 20, 2007·Respiratory Physiology & Neurobiology·Jianhua HuangWoodrow J Weiss
Jul 27, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gianfranco ParatiKrzysztof Narkiewicz
Apr 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Y-J PengN R Prabhakar
Nov 17, 2009·The Journal of Physiology·H J C Ravensbergen, I S Sahota
Jun 16, 2010·Hypertension·Peng ShiMohan K Raizada
Sep 10, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christal G ColemanVirginia M Pickel
Oct 12, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joanna M AbramsJohn W Osborn
Nov 30, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Baojian XueAlan Kim Johnson
May 6, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·W David KnightJ Thomas Cunningham
Nov 13, 2012·Critical Reviews in Biomedical Engineering·Jag Sunderram, Ioannis P Androulakis
Sep 13, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·W David KnightJ Thomas Cunningham
Sep 21, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T Luise KingEileen M Hasser
Oct 8, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Amanda L SharpeGlenn M Toney
Apr 11, 2015·Current Hypertension Reports·Casey Y Carmichael, Richard D Wainford
May 17, 2015·American Journal of Physiology. Cell Physiology·Colin N YoungRobin L Davisson
Jun 10, 2015·Hypertension·Xiao Z ShenPeng Shi
Feb 4, 2016·Current Hypertension Reports·Brent ShellJ Thomas Cunningham
Mar 27, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Heather JamesonDavid Mendelowitz
Jul 31, 2016·Experimental Physiology·Nanduri R Prabhakar
Aug 17, 2016·Autonomic Neuroscience : Basic & Clinical·Hong Zheng, Kaushik P Patel
Dec 23, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Katelynn FaulkJ Thomas Cunningham
Dec 23, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Hale Z TokluNihal Tümer
Jan 7, 2017·Clinical Science·Sinan Khor, Dongsheng Cai
Jan 12, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·W LuL Xu
Jan 26, 2017·Frontiers in Cellular Neuroscience·Radhika RastogiYuchuan Ding

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Citations

May 3, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Heather A DantzlerDavid D Kline
Aug 25, 2020·Psychophysiology·J Richard JenningsPeter J Gianaros
Feb 26, 2019·The Journal of International Medical Research·Bo-Chen YaoZhi-Gang Guo
Oct 27, 2020·Frontiers in Neurology·Caitlin E BrombergTheresa Currier Thomas
Feb 1, 2021·Experimental Gerontology·Fabian-Xosé FernandezDavid C Negelspach
Feb 6, 2020·Trends in Cardiovascular Medicine·Bing HuangHong Jiang
Mar 7, 2021·International Journal of Molecular Sciences·Israel Pérez-TorresVerónica Guarner-Lans
Mar 30, 2021·Anesthesia and Analgesia·Brina SnyderThomas F Floyd

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