Elevated peripheral visfatin levels in narcoleptic patients.

PloS One
N DahmenAlice Engel

Abstract

Narcolepsy is a severe sleep disorder that is characterized by excessive daytime sleepiness, cataplexies and a tendency towards obesity. Recent discoveries indicate that the major pathophysiology is a loss of hypocretin (orexin) producing neurons due to immunologically mediated degeneration. Visfatin is a recently described proinflammatory adipokine. It is identical to the immune modulating pre-B-cell colony enhancing factor (PBEF). Our study examines the hypothesis that visfatin levels are altered in narcoleptic patients. For the analysis, a total of n = 54 patients (n = 18 males and n = 36 females) with the diagnosis of narcolepsy according to DSM-IV and the International Classification of Sleep Disorders were examined (BMI mean 30.3+/-5.5, age mean 52.5+/-16.1 years). As a control group 39 unrelated (n = 12 males and n = 27 females) healthy volunteers with no sleep disorder according to DSM-IV were included (BMI mean 28.5+/-4.6, age mean 51.1+/-13.6 years). Peripheral visfatin levels were measured using a commercial enzyme immunoassay kit with a measurement range from 0.1-1000 ng/ml. Narcolepsy symptoms, severity and frequency of symptoms as well as the total duration of various aspects of the symptomatology were assessed by...Continue Reading

References

Aug 9, 1990·The New England Journal of Medicine·M S Aldrich
Jan 1, 1995·Advances in Neuroimmunology·E MignotF C Grumet
Jan 1, 2000·Lancet·S NishinoE Mignot
Apr 19, 2000·Lancet·A SchuldT Pollmächer
Jun 16, 2001·European Archives of Psychiatry and Clinical Neuroscience·N DahmenM Kasten
Jul 10, 2001·Molecular Psychiatry·Y DauvilliersM Tafti
Feb 14, 2002·Neuroscience Letters·S HiguchiT Sakurai
Jun 12, 2002·Endocrinology and Metabolism Clinics of North America·Alexandros N Vgontzas, George P Chrousos
Jun 26, 2003·Tissue Antigens·S WieczorekN Dahmen
May 26, 2004·Brain, Behavior, and Immunity·M L OkunM E Coussons-Read
Nov 25, 2004·Annals of Neurology·Yves DauvilliersMehdi Tafti
Dec 18, 2004·Science·Atsunori FukuharaIichiro Shimomura
Jan 13, 2006·International Review of Psychiatry·John Logan Black
Sep 19, 2006·Metabolism: Clinical and Experimental·Richard J Wurtman
Sep 20, 2006·Archives of Internal Medicine·Hubertus HimmerichThomas Pollmächer
Sep 26, 2006·Nature Reviews. Immunology·Herbert Tilg, Alexander R Moschen
Sep 28, 2006·Diabetes·Abel López-BermejoJosé-Manuel Fernández-Real
Nov 9, 2006·The Journal of Clinical Endocrinology and Metabolism·Vijayalakshmi VarmaPhilip A Kern
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexander R MoschenHerbert Tilg
Mar 6, 2007·Fertility and Sterility·Te-Fu ChanEing-Mei Tsai
Mar 30, 2007·Journal of Endocrinological Investigation·S PilzW März
Apr 21, 2007·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J HectorP Algenstaedt
Dec 7, 2007·Journal of Pediatric Endocrinology & Metabolism : JPEM·Assimina Galli-TsinopoulouSanda Nousia-Arvanitakis

❮ Previous
Next ❯

Citations

Jun 6, 2009·Acta Physiologica·H TsunekiT Sasaoka

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

Journal of Neurology, Neurosurgery, and Psychiatry
R FronczekE J W Van Someren
Expert Opinion on Pharmacotherapy
Régis Lopez, Yves Dauvilliers
© 2022 Meta ULC. All rights reserved