PMID: 9662270Jul 14, 1998Paper

Elevated plasma endothelin-1 levels in sickle cell anemia: relationships to oxygen saturation and left ventricular hypertrophy

American Journal of Hematology
S G WerdehoffA M Hackman

Abstract

Endothelin-1 (Et-1) is a vasoconstrictor produced by endothelial and vascular smooth muscle cells in response to hypoxia, which induces hypertrophy in cultured cardiac myocytes. We measured plasma Et-1 levels and left ventricular dimensions in 13 patients with sickle cell anemia (SCD) and in 12 African-American controls ages 16-29 years. Endothelin-1 concentrations are significantly higher in SCD subjects than controls (10.6 +/- 1.9 vs. 3.0 +/- 1.3 pmol/L). There was a negative correlation between oxygen saturation and Et-1 levels in SCD patients (r = -0.71, P = 0.01). SCD subjects have more dilated and hypertrophied hearts corrected for body surface area than controls as evidenced by significant increases in left ventricular end diastolic dimension (31 +/- 0.8 vs. 24 +/- 0.9 mm/m2, P < 0.001), left ventricular end systolic dimension (20 +/- 0.9 vs. 16 +/- 0.8 mm/m2, P = 0.002), left ventricular posterior wall thickness (5.0 +/- 0.1 vs. 4.0 +/- 0.1 mm/m2, P < 0.001), and left ventricular mass (125 +/- 7.2 vs. 69 +/- 5.1 g/m2, P < 0.001). The index of left ventricular function, the shortening fraction, was not different between groups (34 +/- 1.2% in SCD vs. 35 +/- 1.5% in controls). The correlation between left ventricular mass...Continue Reading

References

Jun 1, 1978·British Heart Journal·A H ReesJ McFarlane
Jun 1, 1976·The American Journal of Medicine·J L GerryN J Fortuin
Sep 1, 1982·Archives of Internal Medicine·R H Falk, W B Hood
Aug 10, 1995·The New England Journal of Medicine·E R Levin
Jun 1, 1995·Journal of Clinical Pathology·C FerriA Santucci
Aug 15, 1994·Biochemical and Biophysical Research Communications·H KagamuY Mitsui
Mar 1, 1993·Baillière's Clinical Haematology·C T NoguchiG P Rodgers
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·S I HammermanH W Farber

❮ Previous
Next ❯

Citations

Apr 3, 2008·The Journal of Clinical Investigation·Nathalie SabaaPierre-Louis Tharaux
Oct 3, 2002·Annual Review of Medicine·Martin H Steinberg, Carlo Brugnara
May 9, 2002·Expert Opinion on Investigational Drugs·Martin H Steinberg, Carlo Brugnara
May 15, 2013·Journal of Cardiac Failure·Shyam PoludasuJason M Lazar
Oct 9, 2003·Kidney International. Supplement·Arema A Pereira, Mark J Sarnak
Jul 8, 2009·Clinical Biochemistry·Nicola Conran, Fernando F Costa
Jul 26, 2006·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Tim C SpotswoodDavid B Miller
Oct 8, 2003·Hematology·Anil PathareDavid Dennison
Jul 1, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Melinda D WuJonathan R Lindner
Oct 7, 2011·Hemoglobin·Ruby A KhouryMiguel R Abboud
Jul 10, 2002·Journal of the American College of Cardiology·Mark J SarnakAndrew S Levey
Apr 6, 2004·Journal of the American College of Cardiology·Manish G AminMark J Sarnak
Jul 18, 2002·American Journal of Hematology·Vip ViprakasitVoravarn S Tanphaichitr
Feb 3, 2007·American Journal of Hematology·Mark V ZilbermanSharada A Sarnaik
Sep 8, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pierre-Louis TharauxJean-Claude Dussaule
Aug 22, 2003·Critical Care Nursing Quarterly·Allan D Angerio, Nicole D Lee
Jan 25, 2003·Blood·John D BelcherGregory M Vercellotti
Feb 5, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lucia De FranceschiCarlo Brugnara
Dec 17, 2008·Critical Care Nursing Quarterly·Pamela Hodges
Sep 27, 2001·Endothelium : Journal of Endothelial Cell Research·P BarbeauB Gutin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.

Related Papers

American Heart Journal
M A VaratN O Fowler
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
G M London
© 2022 Meta ULC. All rights reserved