Elevated plasma fibrinogen indicates short-term poor outcome in patients with acute ischemic stroke after intravenous thrombolysis

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Dan LiXiangyang Zhu

Abstract

Fibrinogen is a central protein of hemostasis and a major determinant of plasma viscosity and key factor for platelet activation. The aim of this study is to investigate the relationship between fibrinogen level and short-term outcome in acute ischemic stroke patients receiving intravenous thrombolysis. This retrospective study included 176 acute ischemic stroke patients who received intravenous thrombolysis with recombinant tissue plasminogen activator and provided plasma fibrinogen level within 24 h after stroke onset. Patients were categorized by plasma fibrinogen level: Quartile 1 (≤ 1.74 g/L), Quartile 2 (1.75-2.08 g/L), Quartile 3 (2.09-2.69 g/L), and Quartile 4 (> 2.69 g/L). The medical record of each patient was reviewed, and demographic, clinical and laboratory information was abstracted. Functional outcome at 14 days was assessed with the modified Rankin Scale. Poor outcome was present in 75 (42.6%) of the 176 patients that were included in the study (mean age, 72 years; male, 53.4%). After adjustment for potential confounding variables, higher plasma fibrinogen level on admission was associated with poor outcome (adjusted odds ratio 10.45, 95% confidence interval 1.49-73.15 for Q4:Q1; P = 0.02). According to receiver...Continue Reading

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