Elevated plasma fibrinopeptide A and thromboxane B2 levels during cardiopulmonary bypass

Circulation
G C DaviesE W Salzman

Abstract

Patients who underwent operations in which cardiopulmonary bypass was used had elevations of plasma fibrinopeptide A which did not return to normal during bypass despite conventional heparin anticoagulation, suggesting inadequate heparin dosage and continued thrombin activity during the operation. Patients who underwent aortocoronary artery grafting had high plasma thromboxane B2 levels and a rapid fall in platelet count at the onset of extracorporeal circulation. Thromboxane elevations were less marked in patients who underwent valve replacement. Platelet aggregation and coronary artery constriction secondary to thromboxane production may contribute to the morbidity of cardiopulmonary bypass.

References

Mar 1, 1977·AJR. American Journal of Roentgenology·W J Casarella, G D Wilner
Nov 1, 1978·British Journal of Haematology·C N ChestermanF J Morgan
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Nov 16, 1972·The New England Journal of Medicine·L A Harker, S J Slichter
Jan 1, 1972·Transactions - American Society for Artificial Internal Organs·M de LevalF Gerbode
Mar 7, 1974·The New England Journal of Medicine·P P SteeleE Genton
Jun 28, 1969·British Medical Journal·F N McKenzieN A Matheson
Oct 1, 1967·Circulation Research·T BayleyA J Osbahr
Jul 1, 1963·Transfusion·E W SALZMAN

❮ Previous
Next ❯

Citations

Jan 1, 1995·Catheterization and Cardiovascular Diagnosis·J M WilsonJ J Ferguson
Mar 1, 1995·The Annals of Thoracic Surgery·G W HeA Starr
Dec 23, 1985·Life Sciences·G K AsimakisV R Conti
Aug 1, 1994·Biomaterials·J M CourtneyC D Forbes
May 13, 1999·The Annals of Thoracic Surgery·H I Flom-HalvorsenF Brosstad
Mar 1, 1997·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·T MengesG Hempelmann
Dec 1, 1995·Journal of Cardiothoracic and Vascular Anesthesia·N NathanP Feiss
Jun 1, 1995·Journal of Cardiothoracic and Vascular Anesthesia·G P Gravlee
Dec 12, 2003·Nature Reviews. Drug Discovery·Garret A FitzGerald
May 21, 1981·The New England Journal of Medicine·A E BuxtonJ A Kastor
Jul 9, 1981·The New England Journal of Medicine·A L Butler
Feb 17, 2005·The New England Journal of Medicine·Nancy A NussmeierKenneth M Verburg
May 24, 2007·Tissue Engineering·Markus HoenickaDietrich E Birnbaum
Sep 2, 1999·Journal of Cardiovascular Pharmacology·E GeshiT Katagiri
Nov 5, 1999·Journal of Cardiovascular Pharmacology·J L CracowskiP Devillier
Jan 1, 1993·Acta Anaesthesiologica Scandinavica. Supplementum·J H Levy
May 1, 1993·Journal of Cardiac Surgery·L H Edmunds
Dec 10, 1999·Canadian Journal of Physiology and Pharmacology·J L CracowskiG Bessard
Nov 14, 1997·Anesthesia and Analgesia·C HurauxJ H Levy
Dec 25, 2003·Anesthesia and Analgesia·Elmar BerendesMichael Walter
Apr 7, 2007·Journal of Cardiovascular Medicine·Naranjan S DhallaSuresh K Gupta
Apr 1, 1995·American Journal of Hematology·R W Colman
Dec 6, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·P D Raymond, N A Marsh
Sep 1, 1993·Journal of Medical Engineering & Technology·J M Courtney
Jan 4, 2008·Expert Opinion on Drug Safety·Marta L CaponePaola Patrignani
May 9, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Alain BelJohn Pepper
Aug 2, 2011·The Annals of Thoracic Surgery·Milo EngorenRobert H Habib
Jun 30, 2009·The Annals of Thoracic Surgery·Peter RaivioJari Petäjä

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.