Elevated Plasma IL-38 Concentrations in Patients with Acute ST-Segment Elevation Myocardial Infarction and Their Dynamics after Reperfusion Treatment

Mediators of Inflammation
Yucheng ZhongQiutang Zeng

Abstract

Objective. Recent studies suggest that IL-38 is associated with autoimmune diseases. Furthermore, IL-38 is expressed in human atheromatous plaque. However, the plasma levels of IL-38 in patients with ST-segment elevation myocardial infarction (STEMI) have not yet to be investigated. Methods. On admission, at 24 h, at 48 h, and at 7 days, plasma IL-38, C-reactive protein (CRP), cardiac troponin I (cTNI), and N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) levels were measured and IL-38 gene in peripheral blood mononuclear cells (PBMCs) was detected in STEMI patients. Results. The results showed that plasma IL-38 levels and IL-38 gene expression in PBMCs were significantly increased in STEMI patients compared with control group and were time dependent, peaked at 24 h. In addition, plasma IL-38 levels were dramatically reduced in patients with reperfusion treatment compared with control group. Similar results were also demonstrated with CRP, cTNI, and NT-proBNP levels. Furthermore, IL-38 levels were found to be positively correlated with CRP, cTNI, and NT-proBNP and be weakly negatively correlated with left ventricular ejection fraction (LVEF) in STEMI patients. Conclusions. The results indicate that circulating...Continue Reading

References

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Citations

Dec 17, 2017·Immunological Reviews·Charles A Dinarello
Dec 17, 2017·Immunological Reviews·Frank L van de VeerdonkCharles A Dinarello
Mar 16, 2017·Annals of the Rheumatic Diseases·Marie-Astrid BoutetBenoit Le Goff
Nov 21, 2019·Journal of Cellular and Molecular Medicine·Yuzhen WeiQiutang Zeng
May 20, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tingting ZhuYubin Zhang
Aug 8, 2019·Biomolecules·Lihui XieWenru Su
Sep 10, 2020·International Journal of Molecular Sciences·Elaina Melton, Hongyu Qiu
Jul 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Man ChuChun K Wong
Mar 17, 2021·International Immunopharmacology·Hua-Song XiaYan-Qing Wu
Jun 23, 2021·Cytokine·Maryam Zare RafieReza Elahi

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
PCR
Assay

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