Elevated plasma levels of interleukin-16 in patients with acute myocardial infarction

Medicine
Christiana SchernthanerDaniel Kretzschmar

Abstract

Interleukin (IL)-16, a polypeptide cytokine, plays a crucial role in the inflammatory process, acting as a chemoattractant for peripheral immune cells and has been linked to various inflammatory diseases. However, its role in patients with acute myocardial infarction (AMI) is unclear.We retrospectively analyzed serum levels of IL-16 in blood of patients with (STEMI, n = 45) and without ST-segment elevation myocardial infarction (NSTEMI, n = 42) compared with controls with excluded coronary artery disease (n = 55). Furthermore, correlation analysis with inflammatory cells, C-reactive protein (CRP) levels, dendritic cell precursors (DCPs), and other clinical and biochemical markers was performed.Compared with controls, patients with STEMI and NSTEMI evidenced higher levels of IL-16 in pg/mL (STEMI: 759.38 ± 471.54, NSTEMI: 677.77 ± 438.8, control: 500.45 ± 432.21; P = .002). IL-16 correlated with CRP (r = 0.26, P = .001), leucocytes (r = 0.38, P < .001), NT-proBNP (r = 0.20, P = .02) and hsTnT (r = 0.25, P = .004). Circulating myeloid DCPs, plasmacytoid DCPs, and total DCPs showed a significant inverse correlation to IL-16 levels (r = -0.21, P = .01; r = -0.23, P = .005; r = -0.26, P = .002, respectively).Interleukin-16 might pla...Continue Reading

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Citations

Sep 17, 2020·Oncotarget·Victor Hugo de SouzaJeane Eliete Laguila Visentainer
Jul 6, 2021·Journal of Diabetes and Metabolic Disorders·Dalia Ghareeb MohammadShaymaa Abdelraheem
Mar 20, 2020·Current Vascular Pharmacology·Dimitrios PatouliasCharles Faselis
Jun 27, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Line Lobaloba IngobaFrancine Ntoumi

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Methods Mentioned

BETA
blood collection
enzyme-linked immunosorbent assay
ELISA
coronary artery bypass

Software Mentioned

MedCalc
SPSS
CellQuest
SPSSS

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