Elevated plasma levels of lipoprotein(a) in psychiatric patients: a possible contribution to increased vascular risk

European Psychiatry : the Journal of the Association of European Psychiatrists
Enzo EmanuelePierluigi Politi

Abstract

An increased incidence of adverse cardiovascular events has been reported in psychiatric patients, but the exact mechanisms underlying this association are still uncertain. Elevated plasma level of lipoprotein(a) [Lp(a)] is an independent risk factor for atherothrombotic disease in the general population. To study the implications of Lp(a) in psychiatric patients, we measured the plasma levels of Lp(a) in 74 patients with psychiatric disorders (39 schizophrenia, 10 major depression, 13 bipolar disorder and 12 personality disorder) and 74 healthy controls. The Lp(a) levels of the patient groups with schizophrenia, major depression and bipolar disorder were significantly higher than that of the control group. The median Lp(a) value of these diagnostic groups was comparable with those reported in patients with prior atherothrombotic events. On the other hand, no differences were found among personality disorder and controls. Our findings suggest that the elevation of plasma Lp(a) may contribute to increased cardiovascular risk in several patients with psychiatric disorders.

References

May 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·D RouyE Anglés-Cano
Nov 14, 1986·JAMA : the Journal of the American Medical Association·G G RhoadsA L Dannenberg
Nov 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M Bihari-VargaG M Kostner
Jan 1, 1981·Atherosclerosis·G M KostnerG B Qunici
Jan 1, 1995·Progress in Neuro-psychopharmacology & Biological Psychiatry·M Maes
Apr 6, 1994·JAMA : the Journal of the American Medical Association·E J SchaeferR I Levy
Sep 9, 1996·Journal of Affective Disorders·M MaesR Desnyder
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·P N HopkinsR R Williams
Jul 22, 1998·The Psychiatric Clinics of North America·P M PlotskyC B Nemeroff
Jul 22, 1998·Archives of General Psychiatry·D L MusselmanC B Nemeroff
Feb 28, 2002·Psychological Medicine·P PolitiF Barale
Feb 28, 2002·Psychological Medicine·Frederick Cassidy, Bernard J Carroll
Mar 12, 2003·Critical Reviews in Clinical Laboratory Sciences·Giuseppe Lippi, Giancesare Guidi
Mar 22, 2003·Schizophrenia Research·Hildeberto TavaresWagner F Gattaz
Jun 7, 2003·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·James McKenney
Jun 14, 2003·Thyroid : Official Journal of the American Thyroid Association·Haralampos J MilionisMoses S Elisaf
Jul 3, 2003·Schizophrenia Research·Erik MessamoreAaron Janowsky
Aug 2, 2003·Biological Psychiatry·Karen E JoyntChristopher M O'Connor
Nov 26, 2003·European Journal of Clinical Investigation·H J MilionisM S Elisaf
Dec 4, 2003·The British Journal of Psychiatry : the Journal of Mental Science·R G McCreadie, UNKNOWN Scottish Schizophrenia Lifestyle Group
Dec 10, 2003·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Armin ImhofHermann Brenner

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.