Elevated plasma levels of P-selectin glycoprotein ligand-1-positive microvesicles in patients with unprovoked venous thromboembolism

Journal of Thrombosis and Haemostasis : JTH
S JamalyJ-B Hansen

Abstract

Essentials PSGL-1+ microvesicles (MVs) may be important in venous thromboembolism (VTE). We measured plasma levels and parental origin of PSGL-1+ MVs in patients with unprovoked VTE. VTE patients had higher plasma levels of PSGL-1+ MVs than healthy controls. The PSGL-1+ MVs originated mainly from monocytes and endothelial cells. Background Microvesicles (MVs) express antigens from their parental cells and have a highly procoagulant surface. Animal studies suggest that P-selectin glycoprotein ligand-1-positive (PSGL-1+ ) MVs play a role in the pathogenesis of venous thromboembolism (VTE). Objective The aim of this study was to determine plasma levels, the cellular origin and the morphological characteristics of PSGL-1+ MVs in patients with unprovoked VTE. Methods We conducted a population-based case-control study in 20 patients with a history of unprovoked VTE and 20 age- and sex-matched healthy controls recruited from the general population. Plasma levels, the cellular origin and the morphological characteristics of PSGL-1+ MVs were evaluated using flow cytometry, electron microscopy and confocal microscopy. Results Plasma levels of PSGL-1+ MVs were associated with increased risk of VTE. The odds ratio per one standard deviatio...Continue Reading

References

Aug 1, 1986·Journal of Microscopy·K T Tokuyasu
Jul 1, 1974·Journal of Clinical Pathology·S Sevitt
Aug 1, 1981·The Journal of Cell Biology·J W Slot, H J Geuze
Nov 30, 2000·Proceedings of the National Academy of Sciences of the United States of America·P AndréD D Wagner
Feb 15, 2002·British Journal of Haematology·J KappelmayerC Kiss
Aug 12, 2003·Cardiovascular Research·Marja J VanWijkR Nieuwland
Sep 23, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Olivier MorelJean-Marie Freyssinet
Feb 27, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Paula da Costa MartinsJaap-Jan Zwaginga
Jun 6, 2007·Thrombosis and Haemostasis·Paul A KyrleOswald Wagner
Jul 31, 2008·Journal of Thrombosis and Haemostasis : JTH·S K BraekkanJ B Hansen
Nov 22, 2008·Blood·Swapan K DasguptaPerumal Thiagarajan
Nov 5, 2010·Seminars in Thrombosis and Hemostasis·Pavel DavizonJosé A López
May 14, 2011·Circulation Research·A Phillip Owens, Nigel Mackman
Sep 13, 2011·Thrombosis Research·Paolo BucciarelliPier Mannuccio Mannucci
Feb 5, 2013·Expert Review of Hematology·Pierre-Emmanuel Rautou, Nigel Mackman
Sep 10, 2013·Thrombosis Research·Constantine N AntonopoulosChristos D Liapis
May 13, 2014·Thrombosis and Haemostasis·E CampelloP Simioni
May 23, 2015·Cardiovascular Research·Rodger P McEver

❮ Previous
Next ❯

Citations

Mar 29, 2019·Journal of Thrombosis and Haemostasis : JTH·Ina I HøilandJohn-Bjarne Hansen
Jun 20, 2019·International Journal of Molecular Sciences·Marta ZaràSilvia Stella Barbieri
Nov 8, 2019·Antioxidants & Redox Signaling·Lina BadimonGemma Chiva-Blanch
Jan 10, 2022·Journal of Thrombosis and Haemostasis : JTH·Omri SnirJohn-Bjarne Hansen

❮ Previous
Next ❯

Related Concepts