Elevated plasma N-terminal pro-brain natriuretic peptide levels in acute ischemic stroke

American Heart Journal
Kenan IltumurNizamettin Toprak

Abstract

B-type natriuretic peptide (BNP) is a neurohormone secreted mainly in the cardiac ventricles in response to volume expansion and pressure overload. The aim of this study was to assess plasma N-terminal proBNP (NT-proBNP) changes in acute ischemic stroke (AIS). The study group consisted of 57 (37 women aged 64 +/- 12 years) patients who had their first AIS and no history or signs of cardiovascular disease. An age-matched control group was also included (n = 57, 36 women aged 61 +/- 6 years). NT-proBNP, troponin I (TnI), and creatine kinase-MB were evaluated. A thorough cardiovascular and neurological investigation, including imaging techniques and lesion size determination, was also performed. The log NT-proBNP peak levels, TnI, and creatine kinase-MB levels were significantly higher in AIS compared with controls (7.25 +/- 1.77 vs 3.48 +/- 0.76 pg/mL, P < .0001; 0.76 +/- 0.54 vs 0.5 +/- 0.0 ng/mL, P < .001; 57 +/- 37 vs 13 +/- 4 U/L, P < .001, respectively). The log NT-proBNP correlated positively with TnI (r = 0.29, P = .03) and heart rate (r = 0.41, P = .002), and negatively with left ventricular ejection fraction (r = -0.67, P < .0001). Patients with signs of marked myocardial ischemia and patients with insular cortex involve...Continue Reading

Associated Clinical Trials

References

Jul 1, 1977·Stroke; a Journal of Cerebral Circulation·J Dimant, D Grob
Sep 1, 1989·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·N B SchillerI Schnittger
May 1, 1985·Archives of Internal Medicine·N R HertzerL C Maljovec
Nov 1, 1984·Stroke; a Journal of Cerebral Circulation·A Kolin, J W Norris
Mar 4, 1998·Current Opinion in Neurology·S Sen, S M Oppenheimer
Aug 26, 1998·Stroke; a Journal of Cerebral Circulation·S L DawsonJ F Potter
Aug 26, 1998·Stroke; a Journal of Cerebral Circulation·M TomidaK Yamasaki
Jul 2, 1999·Stroke; a Journal of Cerebral Circulation·S L TokgözogluA Oto
Oct 12, 2000·Journal of the American College of Cardiology·N ParekhC Rickard
Aug 9, 2001·European Heart Journal·W J RemmeUNKNOWN Task Force for the Diagnosis and Treatment of Chronic Heart Failure, European Society of Cardiology
Oct 6, 2001·The New England Journal of Medicine·J A de LemosE Braunwald
Jan 10, 2002·Stroke; a Journal of Cerebral Circulation·Hakan AyOkay Saribaş
Jun 8, 2002·Stroke; a Journal of Cerebral Circulation·Takashi MasudaTohru Izumi
Jul 20, 2002·International Journal of Cardiology·C DalyM Henein
Aug 21, 2002·Cerebrovascular Diseases·George Khechinashvili, Kjell Asplund
Dec 13, 2003·Stroke; a Journal of Cerebral Circulation·John R LynchDaniel T Laskowitz

❮ Previous
Next ❯

Citations

Feb 9, 2012·Cardiovascular Research·Hans Erik BøtkerWon Yong Kim
Mar 16, 2011·International Journal of Clinical Practice·J C Sharma, N Sharma
Dec 17, 2008·BMC Neurology·Kazushi YukiiriMasakazu Kohno
Oct 5, 2012·Cardiovascular Diabetology·Henrik ReinhardPeter K Jacobsen
Oct 31, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hirofumi TomitaKen Okumura
Oct 1, 2008·Biomarkers in Medicine·Jesper K Jensen
Mar 24, 2011·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Miroslava Zivković, Srdjan Ljubisavljević
Jul 11, 2013·Cardiovascular Psychiatry and Neurology·Buse HasırcıAbdulkadir Koçer
Sep 22, 2007·Scandinavian Cardiovascular Journal : SCJ·Jesper K JensenHans Mickley
Dec 17, 2014·International Journal of Cardiology·Michal KrálDavid Školoudík
Apr 10, 2013·The American Journal of Cardiology·Michal KrálDavid Školoudík
Feb 21, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Shokoufeh HajsadeghiScott Reza Jafarian Kerman
Jul 27, 2010·Journal of the American Society of Hypertension : JASH·Michiaki NagaiKazuomi Kario
Apr 13, 2010·Neurosurgery Clinics of North America·Alan H YeeEelco F M Wijdicks
Dec 23, 2008·International Journal of Cardiology·Pierre AmbrosiMarc Heim
May 13, 2008·European Journal of Internal Medicine·M Cerdà-EsteveJ Roquer
May 22, 2007·Journal of the Neurological Sciences·Emanuele Di AngelantonioMarco Fiorelli
May 23, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Murat BitekerCemile Handan Mısırlı
Mar 8, 2013·Acta Neurologica Scandinavica·A C FonsecaJ M Ferro
Jun 8, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Ana Catarina FonsecaJosé M Ferro
Mar 14, 2007·The American Journal of Cardiology·Jesper K JensenHans Mickley
Jul 7, 2009·The American Journal of Cardiology·Jesper K JensenJames L Januzzi
Aug 4, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Shinya KawaseKenji Nakashima
Aug 4, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Charlotte ThålinSara Aspberg
Jan 24, 2012·Lancet Neurology·Peter Sörös, Vladimir Hachinski
Jan 17, 2012·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Amir DarkiJohn T Barron
Nov 3, 2007·Cardiology·Christian M Jespersen, Jørgen Fischer Hansen
Oct 25, 2008·Stroke; a Journal of Cerebral Circulation·Daniel T LaskowitzUNKNOWN BRAIN Study Group
Feb 28, 2008·Current Opinion in Cardiology·Debra L Isaac
Oct 27, 2015·Medizinische Klinik, Intensivmedizin und Notfallmedizin·F JansenN Werner
Apr 2, 2020·International Journal of Molecular Sciences·Chengyang XuZhipeng Cao
Apr 9, 2021·Wellcome Open Research·Usha K MisraUNKNOWN Tuberculous Meningitis International Research Consortium

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Stroke; a Journal of Cerebral Circulation
A M MäkikallioV V Myllylä
Stroke; a Journal of Cerebral Circulation
John R LynchDaniel T Laskowitz
© 2022 Meta ULC. All rights reserved