Elevated Plasma X-Linked Neuroligin 4 Expression Is Associated with Autism Spectrum Disorder.

Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
Laila Yousef Al-AyadhiNadra E Elamin

Abstract

In this study, we compared plasma levels of neuroligin 4 (NLGN4) in children with autism versus matched healthy controls to examine a possible correlation between plasma NLGN4 and degree of autism severity as well as social impairment in autistic patients. 88 autistic patients aged 3-12 years and 33 age- and sex-matched controls aged 3-9 years were recruited. Plasma levels of NLGN4 were determined using a commercial enzyme-linked immunoassay (ELISA). The Childhood Autism Rating Scale (CARS) and the Social Responsiveness Scale (SRS) were used to assess cognitive dysfunction and social impairment in autistic patients. Plasma levels of NLGN4 were significantly higher (p = 0.001) in autistic children than in healthy controls. Despite alterations in the levels of NLGN4 in the subgroups of the autistic children, no correlation between plasma concentration of NLGN4 and cognitive problems or social impairment was observed (p> 0.05). Increased plasma concentrations of NLGN4 may play a role in the pathogenesis of autism, and it could be a valuable biomarker for autism. Further studies with larger sample sizes are warranted to validate this finding and also to explore the potential links between NLGN4 and the features of autism.

References

Apr 2, 2003·Nature Genetics·Stéphane JamainUNKNOWN Paris Autism Research International Sibpair Study
Feb 14, 2004·American Journal of Human Genetics·Frédéric LaumonnierSylvain Briault
May 4, 2004·Pediatrics·Rebecca MuhleIsabelle Rapin
May 20, 2004·Human Molecular Genetics·Ben ChihPeter Scheiffele
Feb 1, 2005·Science·Ben ChihPeter Scheiffele
May 2, 2006·Journal of Medical Genetics·Z TalebizadehM G Butler
Oct 31, 2006·Brain : a Journal of Neurology·A HyeS Lovestone
Sep 4, 2007·Journal of Autism and Developmental Disorders·Linda C Eaves, Helena H Ho
Sep 4, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chen ZhangThomas C Südhof
Sep 9, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Gene J Blatt, S Hossein Fatemi
Apr 13, 2012·Autism Research : Official Journal of the International Society for Autism Research·Mayada ElsabbaghEric Fombonne
Oct 23, 2012·Neuron·Kunimichi SuzukiTakeshi Iwatsubo
Oct 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Magali H AronsCraig C Garner
May 28, 2013·Human Molecular Genetics·Lingling ShiKai Wang
Mar 13, 2014·Autism Research : Official Journal of the International Society for Autism Research·Thomas C JaramilloCraig M Powell
Jan 18, 2017·Acta Neurobiologiae Experimentalis·Geir BjorklundMauricio A Urbina
Sep 23, 2018·Molecular Psychiatry·Michael A BembenKatherine W Roche
May 24, 2019·Autism Research : Official Journal of the International Society for Autism Research·Suzanne HosieElisa L Hill-Yardin

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