Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility

Physiological Reviews
Hong-Long JiMichael A Matthay


Patients with hypertension, diabetes, coronary heart disease, cerebrovascular illness, chronic obstructive pulmonary disease, and kidney dysfunction have worse clinical outcomes when infected with SARS-CoV-2, for unknown reasons. The purpose of this review is to summarize the evidence for the existence of elevated plasmin(ogen) in COVID-19 patients with these comorbid conditions. Plasmin, and other proteases, may cleave a newly inserted furin site in the S protein of SARS-CoV-2, extracellularly, which increases its infectivity and virulence. Hyperfibrinolysis associated with plasmin leads to elevated D-dimer in severe patients. The plasmin(ogen) system may prove a promising therapeutic target for combating COVID-19.

Associated Clinical Trials

Mar 30, 2021·Nahla Mohamed Mohamed Mahmoud


Mar 1, 1982·The Journal of Clinical Investigation·W W McGuireC G Cochrane
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·T Fuchs-BuderP M Suter
Apr 14, 2000·International Journal of Molecular Medicine·Y CaoD Zurakowski
Jan 5, 2002·The Journal of Biological Chemistry·Scott H DonaldsonSherif E Gabriel
May 6, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Priya PrabhakaranMitchell A Olman
Feb 1, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Carole PlanèsBernard Rossier
Feb 3, 2005·The Journal of Infectious Diseases·Zhinan ChenPing Zhu
Sep 10, 2005·Endocrinology·Peter M Snyder
May 19, 2006·Journal of Thrombosis and Haemostasis : JTH·M C DrinaneM J Mulligan-Kehoe
Mar 7, 2007·Current Topics in Developmental Biology·Carole Planès, George H Caughey
Oct 4, 2008·Annual Review of Physiology·Douglas C EatonLucky Jain
Oct 22, 2008·Annual Review of Physiology·Bernard C Rossier, M Jackson Stutts
Dec 30, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hong-Long JiSadis Matalon
Jan 10, 2009·American Journal of Respiratory Cell and Molecular Biology·Ahmed LazrakSadis Matalon
Oct 30, 2009·Current Opinion in Nephrology and Hypertension·Christopher J PasseroThomas R Kleyman
Jun 18, 2010·The New England Journal of Medicine·Sara F GoldkindBeverly Gallauresi
Apr 25, 2013·The Journal of Biological Chemistry·Brian S Hamilton, Gary R Whittaker
Nov 22, 2013·Journal of Virology·Longping V TseGary R Whittaker
Oct 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jean Kaoru Millet, Gary R Whittaker
Dec 3, 2014·Virus Research·Jean Kaoru Millet, Gary R Whittaker
Dec 11, 2014·Journal of the American Society of Hypertension : JASH·Christina S OxlundBoye L Jensen
Jan 23, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Henrik AndersenBoye L Jensen
Oct 4, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sadis MatalonJames F Collawn

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Methods Mentioned

bronchoalveolar lavage

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