Elevated platelet microparticle levels in valvular atrial fibrillation

Hematology
Hanan Azzam, Maged Zagloul

Abstract

Platelet activation occurs in peripheral blood of patients with rheumatic mitral stenosis (MS) and atrial fibrillation (AF) and could be related to abnormal thrombogenesis. However, the plasma level of platelet microparticles (PMPs), a marker of platelet activation, in patients with valvular AF remains unresolved. We performed a case control study of 20 patients with chronic rheumatic MS and chronic long AF and 10 healthy volunteers who were in sinus rhythm. Peripheral plasma levels of PMP were assessed by quantifying CD41-positive microparticles by flow cytometry. The mitral valve area was calculated by means of the Doppler pressure half-time method. The levels of circulating PMP were elevated significantly in valvular AF patients when compared with controls (12.36+/-5.51 x 10(5)/ml versus 7.56+/-0.86 x 10(5)/ml, P=0.011). Correlation analysis demonstrated that there was a significantly direct relationship between the severity of MS and PMP levels (r=-0.507, P=0.004). We conclude that in patients with rheumatic MS and AF, there is evidence of platelet activation detected by high PMP levels which have a significantly direct relationship with the severity of MS.

References

Oct 1, 1974·Circulation Research·P D Stein, H N Sabbah
Feb 1, 1980·Science·V T Turitto, H J Weiss
Jan 1, 1995·Blood Cells, Molecules & Diseases·W JyY S Ahn
Jul 3, 1998·The Journal of Clinical Investigation·O P BarryG A FitzGerald
Feb 13, 2001·Cardiovascular Research·D EnglishD N Brindley
Jul 26, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·H K KimS N Lee
Jan 7, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ingrid MüllerBernd Engelmann
Feb 8, 2003·Hypertension·Richard A PrestonYeon S Ahn
Jun 11, 2003·American Heart Journal·Leon Bernal-MizrachiYeon S Ahn
Oct 16, 2003·International Journal of Cardiology·Ertan YetkinSengul Cehreli

❮ Previous
Next ❯

Citations

Aug 11, 2010·Journal of Thrombosis and Haemostasis : JTH·E ShantsilaG Y H Lip
Nov 14, 2014·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Yuan I Scarlet ChouYongzhen Zhang
Apr 23, 2019·Annals of Medicine·Christos VoukalisGregory Y H Lip
Jun 2, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Andreas ZietzerFelix Jansen
Jul 13, 2021·Heart Failure Reviews·Kun XiangChengming Fan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.