Elevated pretreatment serum levels of soluble vascular cell adhesion molecule 1 and lactate dehydrogenase as predictors of survival in cutaneous metastatic malignant melanoma

British Journal of Cancer
A FranzkeJ Atzpodien

Abstract

Very rapid progression of disease with a median survival of 6-9 months is a common feature of metastatic cutaneous malignant melanoma. Nevertheless, substantial variability of survival suggests that metastatic cutaneous malignant melanoma can be divided into several biological subgroups. Pretreatment serum levels of soluble adhesion molecules and various clinical parameters in cutaneous metastatic malignant melanoma were evaluated to determine their prognostic value. In this study pretreatment serum levels of soluble vascular cell adhesion molecule 1 (sVCAM-1), soluble intercellular cell adhesion molecule 1 (sICAM-1), soluble endothelial leukocyte adhesion molecule 1 (sE-selectin) and multiple clinical factors were assessed in relation to overall survival of 97 consecutive patients with metastatic cutaneous malignant melanoma seen at our institution between May 1990 and April 1996. For statistical analysis, both univariate and multivariate Cox proportional-hazards models were used. Elevated pretreatment serum levels of sVCAM-1 (P < 0.005) and of lactate dehydrogenase (P < 0.002) were rendered statistically independent and were significantly associated with unfavourable outcome. Patients were assigned to one of three risk catego...Continue Reading

Citations

Aug 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M BalchA Morabito
Jun 29, 2004·Journal of Surgical Oncology·John F ThompsonRichard A Scolyer
Mar 28, 2008·Annals of Surgical Oncology·Yuji ToiyamaMasato Kusunoki
Jun 27, 2009·Cancer Control : Journal of the Moffitt Cancer Center·Selma UgurelJürgen C Becker
Feb 23, 2005·Expert Review of Molecular Diagnostics·Gerald P LinetteJeffrey S Ross
Dec 3, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ahmad A TarhiniJohn M Kirkwood
Aug 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M BalchJ F Thompson
Aug 22, 2000·The British Journal of Dermatology·L Brochez, J M Naeyaert
Jan 16, 2007·Archives of Dermatological Research·Jochen UtikalSelma Ugurel
Jan 20, 2005·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·S Ugurel
Jan 1, 2009·Folia Histochemica Et Cytobiologica·M ManturD Lemancewicz
Jan 23, 2010·Melanoma Research·Roger MouawadDavid Khayat
Feb 6, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mengze HaoJilong Yang
Mar 16, 2017·The Journal of Dermatology·Hajime MiyazawaHiroshi Shimizu
Dec 21, 2000·Current Oncology Reports·A C Buzaid, C M Anderson
Jul 24, 2002·Journal of Cutaneous Pathology·Ning LiJag Bhawan
Apr 6, 2007·Endocrine Reviews·Robert R Langley, Isaiah J Fidler
Oct 11, 2002·Annals of Surgical Oncology·Peter J Allen, Daniel G Coit
Jul 4, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L E FlahertyW Du
Mar 22, 2002·Cancer Control : Journal of the Moffitt Cancer Center·Christina J KimUNKNOWN AJCC Melanoma Staging Committee
Oct 12, 2012·Amino Acids·Nadine TandlerJens Pietzsch
Mar 7, 2002·Current Opinion in Oncology·Peter J Allen, Daniel G Coit
Jan 31, 2002·Journal of Chromatography. B, Biomedical Sciences and Applications·J Hartleb, R Arndt
Nov 27, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D AlexiouC Tsigris
Jan 15, 2000·La Revue de médecine interne·A PierresP Bongrand
Feb 22, 2005·Lancet·John F ThompsonRichard F Kefford
Aug 25, 2005·The Journal of Investigative Dermatology·Irene J VergilisSandra R Reynolds
Mar 18, 2003·Seminars in Oncology Nursing·Lynne A LambWen-Jen Hwu
Jun 11, 2004·Seminars in Oncology·Dennis L Rousseau, Jeffrey E Gershenwald
Aug 16, 2005·Current Problems in Surgery·Thomas A Aloia, Jeffrey E Gershenwald

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