Elevated prolactin serum levels and history of alcohol withdrawal seizures

Journal of Psychiatric Research
Thomas HillemacherStefan Bleich

Abstract

Prolactin has been discussed to be useful for differential diagnosis in epilepsia. Aim of the present study was to investigate the association between prolactin serum levels and previous alcohol withdrawal seizures. We assessed 118 male patients admitted for detoxification treatment. Previous withdrawal seizures were recorded and prolactin serum levels were measured using an enzymatic immunoassay. Patients with a history of alcohol withdrawal seizures had significantly higher prolactin levels (17.8 ng/ml, SD=12.1) than patients without previous seizures (13.0 ng/ml, SD=8.1, p<0.05). Logistic regression revealed significant predictive qualities for prolactin serum levels (B=0.05, Wald=5.30, p=0.021, OR=1.06, 95%CI=1.01-1.11). The present findings show an association between elevated prolactin serum levels and a history of withdrawal seizures. Hence, the results suggest that prolactin elevation at admission may be a clinical marker for an increased risk of withdrawal seizures.

References

Sep 1, 1991·British Journal of Addiction·T F HeathertonK O Fagerström
May 7, 1971·Biochemical and Biophysical Research Communications·A H TashjianD K Jensen
Jan 1, 1995·Journal of Neural Transmission. General Section·A HeinzH Rommelspacher
Oct 1, 1996·European Journal of Endocrinology·L PinillaE Aguilar
Mar 24, 1998·Annual Review of Medicine·G Tsai, J T Coyle
Aug 8, 1998·European Journal of Pharmacology·C BregonzioA O Donoso
Jul 22, 1999·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·T WetterlingU John
Aug 24, 1999·Seizure : the Journal of the British Epilepsy Association·I LusićV Capkun
Sep 8, 2000·Neuroreport·S BleichJ Kornhuber
Jul 27, 2001·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·G A WiesbeckJ Boening
Aug 29, 2001·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·A HelanderB Zakrisson
Dec 12, 2001·Endocrine Reviews·N Ben-Jonathan, R Hnasko
Jun 24, 2004·Cellular and Molecular Neurobiology·Claudia BregonzioAlfredo O Donoso
Jul 17, 2004·Epilepsy & Behavior : E&B·Garima ShuklaSatish Jain
Mar 17, 2005·Alcoholism, Clinical and Experimental Research·Stefan BleichJohannes Kornhuber
May 21, 2005·Alcohol·Thomas HillemacherStefan Bleich
Jun 15, 2005·Biological Psychiatry·Kristina BayerleinStefan Bleich
Sep 30, 2005·Addiction Biology·Thomas HillemacherStefan Bleich

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Citations

Aug 10, 2006·Journal of Neural Transmission·T HillemacherS Bleich
May 25, 2012·Journal of Neural Transmission·Thomas HillemacherJohannes Kornhuber
Dec 12, 2007·Alcoholism, Clinical and Experimental Research·Yann Le StratPhilip Gorwood
Jan 31, 2012·European Addiction Research·Deniz KaragülleThomas Hillemacher
Dec 3, 2010·Alcoholism, Clinical and Experimental Research·Julia WilhelmThomas Hillemacher

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