PMID: 9434102Jan 20, 1998Paper

Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease

Biochimica Et Biophysica Acta
D S CassarinoJ P Bennett

Abstract

The dopaminergic neurotoxin N-methyl,4-phenyl-1,2,3,6 tetrahydropyridine (MPTP) causes a syndrome in primates and humans which mimics Parkinson's disease (PD) in clinical, pathological, and biochemical findings, including diminished activity of complex I in the mitochondrial electron transport chain. Reduced complex I activity is found in sporadic PD and can be transferred through mitochondrial DNA, suggesting a mitochondrial genetic etiology. We now show that MPTP treatment of mice and N-methylpyridinium (MPP+) exposure of human SH-SY5Y neuroblastoma cells increases oxygen free radical production and antioxidant enzyme activities. Cybrid cells created by transfer of PD mitochondria exhibit similar characteristics; however, PD cybrids' antioxidant enzyme activities are not further increased by MPP+ exposure, as are the activities in control cybrids. PD mitochondrial cybrids are subject to metabolic and oxidative stresses similar to MPTP parkinsonism and provide a model to determine mechanisms of oxidative damage and cell death in PD.

References

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Citations

Mar 19, 1999·Journal of Neuroscience Research·C P Fall, J P Bennett
Sep 17, 2008·Journal of Molecular Neuroscience : MN·Margarida Castro-CaldasMaria João Gama
Apr 28, 2012·Molecular Neurobiology·Margarida Castro-CaldasMaria João Gama
Jan 9, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Kang-Woo LeeM Maral Mouradian
Jul 25, 2003·European Journal of Pharmacology·Xiao-Chun ChenChao-Hui Zhao
Nov 24, 1999·Journal of the Neurological Sciences·J P Bennett
Jul 13, 1999·Neurochemistry International·T IantomasiM T Vincenzini
Apr 13, 2000·Neurochemistry International·J SeyfriedU Wüllner
Oct 17, 1998·Burns : Journal of the International Society for Burn Injuries·B LathaM Babu
Dec 25, 2002·Free Radical Biology & Medicine·Jos L VeneroAlberto Machado
Apr 2, 2011·The Journal of Biological Chemistry·Yi WenShao-Hua Yang
Mar 10, 2005·The Journal of Biological Chemistry·Jason CallioCharleen T Chu
Apr 20, 2006·The Journal of Biological Chemistry·Elisabeth M ChalovichCharleen T Chu
Mar 18, 2003·The Journal of Clinical Investigation·Jeffrey A Klein, Susan L Ackerman
Jun 19, 2009·Molecular Neurodegeneration·Patricia A TrimmerUri Oron
Apr 1, 2014·Molecular Medicine Reports·Da-Wei LiGuang-Ren Li
Jan 19, 2010·Annual Review of Pathology·Douglas C WallaceVincent Procaccio
Jan 8, 2014·Journal of Molecular Neuroscience : MN·Yumin WangHongquan Wang
Mar 15, 2014·Disease Models & Mechanisms·Kelley C O'DonnellAlvaro Sagasti
Aug 5, 2015·Scientific Reports·Benjamin DelatteFrançois Fuks

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