Elevated Red Blood Cell Distribution Width May Be a Novel Independent Predictor of Poor Functional Outcome in Patients Treated with Mechanical Thrombectomy.

Neurointervention
Cetin Kursad AkpinarAtilla Ozcan Ozdemir

Abstract

Red blood cell distribution width (RDW) evaluates the variation (size heterogeneity) in red blood cells. Elevated RDW has been identified as a predictor of poor functional outcomes for acute ischemic stroke. The association between elevated RDW level and poor functional outcome in stroke patients undergoing mechanical thrombectomy has not been reported before. This study aims to investigate this relationship. This was a multicenter retrospective study involving the prospectively and consecutively collected data of 205 adult stroke patients who underwent mechanical thrombectomy for anterior circulation large vessel occlusion (middle cerebral artery M1, anterior cerebral artery A1, tandem ICA-MCA, carotid T) between July 2017 and December 2019. RDW cut off levels were accepted as >16%. The effect of elevated RDW on poor functional outcome (modified Rankin scale 3-6) was investigated using bivariate and multivariate regression analysis. Elevated RDW was significantly associated with poor functional outcome in bivariate and multivariate analysis (odds ratio [OR] for RDW >16%, 2.078; 95% confidence interval [95% CI], 1.083-3.966; P=0.027 and OR for RDW >16%, 2.873; 95% CI, 1.342-6.151; P=0.007; respectively). These findings suggest ...Continue Reading

References

Jan 29, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Iain C Macdougall, Angela Cooper
Jan 4, 2008·Circulation·Marcello TonelliUNKNOWN for the Cholesterol and Recurrent Events (CARE) Trial Investigators
Nov 26, 2008·Journal of the Neurological Sciences·Chizobam Ani, Bruce Ovbiagele
Apr 17, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Martina MontagnanaGiuseppe Lippi
Oct 30, 2012·Archives of Gerontology and Geriatrics·Zeynel Abidin ÖztürkYalçın Kepekçi
Jun 28, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Ahmet KayaIbrahim Halil Tanboga
Jul 25, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Jose M Ramírez-MorenoAna B Constantino-Silva
Oct 3, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Recep DemirHizir Ulvi
Dec 20, 2013·Current Treatment Options in Cardiovascular Medicine·Hardik Amin, David M Greer
Jun 20, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe Lippi, Mario Plebani
Dec 24, 2014·Critical Reviews in Clinical Laboratory Sciences·Gian Luca SalvagnoGiuseppe Lippi
Apr 4, 2015·Neuropsychiatric Disease and Treatment·Hasan KaraSeyit Ali Kayis
Aug 21, 2015·Thrombosis and Haemostasis·Jostein LappegårdJohn-Bjarne Hansen
Oct 11, 2017·Stroke and Vascular Neurology·Gang-Hua FengRen-Bin Huang
Jul 26, 2019·Oxidative Medicine and Cellular Longevity·Sebastian StevenAndreas Daiber

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Citations

Jun 5, 2021·Brain Circulation·Jeffrey Farooq, Jea Young Lee

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