PMID: 8448611Mar 1, 1993Paper

Elevated resting heart rate in rheumatoid arthritis: possible role of physical deconditioning

British Journal of Rheumatology
S J Piha, L M Voipio-Pulkki

Abstract

Thirty-four patients with RA, 76 diabetic subjects (DM) and 67 healthy controls (CR) were studied in order to study cardiovascular autonomic function in RA. Valsalva manoeuvre, deep breathing test and active orthostatic test were used. Resting heart rate (resting HR) was markedly elevated in the RA and DM groups. Therefore, the groups were compared using analysis of variance with age and resting HR as covariates. The analyses showed no differences in cardiovascular responses between the RA group and CR group but cardiovascular responses were significantly diminished in the DM group compared with both the CR group and RA group. Our data indicate that the parasympathetic efferent pathway mediating cardiovascular reflexes via the nervus vagus is intact in RA. Thus elevated resting HR in RA does not seem to be due to peripheral parasympathetic damage. Physical deconditioning may explain the elevation of resting HR in patients with RA.

Citations

Jun 18, 1998·Annals of the New York Academy of Sciences·A KavelaarsC J Heijnen
Jul 13, 2002·Annals of the New York Academy of Sciences·Luca BertinottiMarco Matucci-Cerinic
Aug 18, 2012·International Journal of Rheumatic Diseases·Dina C Janse van RensburgLizelle Fletcher
Oct 20, 2012·BMC Musculoskeletal Disorders·Tjerk MunstermanHarriet Wittink
May 19, 2010·Arthritis Research & Therapy·Sabine J M de BrouwerAndrea W M Evers
Nov 28, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Alice LaudisioRaffaele Antonelli Incalzi
Aug 26, 2014·Seminars in Arthritis and Rheumatism·Ahmed M AdlanJames P Fisher
May 12, 2016·BMC Cardiovascular Disorders·Ahmad OsailanJet J C S Veldhuijzen van Zanten
Aug 4, 2020·PloS One·Laurette van BoheemenMichael T Nurmohamed
Dec 1, 1994·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·C H Stenström
Nov 1, 1994·Archives of Physical Medicine and Rehabilitation·K K LyngbergB Danneskiold-Samsøe

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